Reactome | E2F1 binds PMAIP1 (NOXA) promoter

Schema > Reaction > Entries

authored	[InstanceEdit:4217521] Orlic-Milacic, M, 2013-08-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4331328] Orlic-Milacic, M, 2013-08-16
dbId	4331327
displayName	E2F1 binds PMAIP1 (NOXA) promoter
eventOf	[Pathway:R-HSA-111448] Activation of NOXA and translocation to mitochondria - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-140217] Transactivation of PMAIP1 (NOXA) by E2F1 - Homo sapiens
input	[Complex:R-HSA-68653] E2F1:TFDP1,TFDP2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4331342] PMAIP1 Gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141113] Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1 binds PMAIP1 (NOXA) promoter
output	[Complex:R-HSA-4331338] E2F1:TFDP1:PMAIP1 Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4331327
summation	[Summation:4331341] E2F1, in complex with TFDP1 (DP-1), binds the promoter of PM...

(hasEvent)	[Pathway:R-HSA-111448] Activation of NOXA and translocation to mitochondria
(precedingEvent)	[BlackBoxEvent:R-HSA-140217] Transactivation of PMAIP1 (NOXA) by E2F1

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