Reactome | PP2A mediated localization of RB1 protein in chromatin

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PP2A mediated localization of RB1 protein in chromatin Show undefined attributes

catalystActivity	[CatalystActivity:113757] phosphoprotein phosphatase activity of PP2A [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
dbId	113503
displayName	PP2A mediated localization of RB1 protein in chromatin
eventOf	[Pathway:R-HSA-113501] Inhibition of replication initiation of damaged DNA by RB1/E2F1 - Homo sapiens
followingEvent	[Reaction:R-HSA-113643] Replication initiation regulation by Rb1/E2F1 - Homo sapiens
input	14 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-188389] hyperphosphorylated RB1 [nucleoplasm] [Complex:R-ALL-113656] RNA primer-DNA primer:origin duplex with DNA damage [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:113670] Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. [LiteratureReference:1362454] Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation [LiteratureReference:9027066] RB-dependent S-phase response to DNA damage
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	PP2A mediated localization of RB1 protein in chromatin
orthologousEvent	[Reaction:R-MMU-113503] PP2A mediated localization of RB1 protein in chromatin - Mus musculus [Reaction:R-DDI-113503] PP2A mediated localization of RB1 protein in chromatin - Dictyostelium discoideum [Reaction:R-DRE-113503] PP2A mediated localization of RB1 protein in chromatin - Danio rerio [Reaction:R-SSC-113503] PP2A mediated localization of RB1 protein in chromatin - Sus scrofa [Reaction:R-BTA-113503] PP2A mediated localization of RB1 protein in chromatin - Bos taurus [Reaction:R-CFA-113503] PP2A mediated localization of RB1 protein in chromatin - Canis familiaris [Reaction:R-RNO-113503] PP2A mediated localization of RB1 protein in chromatin - Rattus norvegicus
output	14 × [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-113646] RB1:RNA primer-DNA primer:origin duplex with DNA damage [nucleoplasm]
precedingEvent	[Reaction:R-HSA-113504] Detection of damage during initiation of DNA synthesis in S-phase - Homo sapiens [Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Homo sapiens [Reaction:R-HSA-188390] Cyclin E:CDK2-mediated phosphorylation of RB1 - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-113503
summation	[Summation:179100] Dephoshorylation of RB1 by the PP2A complex containing the r...

Referrals

(hasEvent)	[Pathway:R-HSA-113501] Inhibition of replication initiation of damaged DNA by RB1/E2F1
(precedingEvent)	[Reaction:R-HSA-113643] Replication initiation regulation by Rb1/E2F1