Reactome | RB1 translocates to the nucleus

Schema > BlackBoxEvent > Entries

RB1 translocates to the nucleus Show undefined attributes

authored	[InstanceEdit:9018019] Orlic-Milacic, Marija, 2017-08-29
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9659824] Orlic-Milacic, Marija, 2019-09-06
dbId	9659820
displayName	RB1 translocates to the nucleus
edited	[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
eventOf	[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
followingEvent	[Reaction:R-HSA-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes - Homo sapiens [Reaction:R-HSA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Homo sapiens [Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9660621] RB1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9660620] A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	RB1 translocates to the nucleus
orthologousEvent	[BlackBoxEvent:R-DDI-9659820] RB1 translocates to the nucleus - Dictyostelium discoideum [BlackBoxEvent:R-GGA-9659820] RB1 translocates to the nucleus - Gallus gallus [BlackBoxEvent:R-XTR-9659820] RB1 translocates to the nucleus - Xenopus tropicalis [BlackBoxEvent:R-DRE-9659820] RB1 translocates to the nucleus - Danio rerio [BlackBoxEvent:R-SSC-9659820] RB1 translocates to the nucleus - Sus scrofa [BlackBoxEvent:R-BTA-9659820] RB1 translocates to the nucleus - Bos taurus [BlackBoxEvent:R-CFA-9659820] RB1 translocates to the nucleus - Canis familiaris [BlackBoxEvent:R-RNO-9659820] RB1 translocates to the nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-9659820] RB1 translocates to the nucleus - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-68642] RB1 [nucleoplasm]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9659820
summation	[Summation:9661226] Amino acid residues 860-876 in the C terminal part of RB1 co...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9660615] Defective RB1 does not translocate to the nucleus
(hasEvent)	[Pathway:R-HSA-69231] Cyclin D associated events in G1
(precedingEvent)	[Reaction:R-HSA-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes [Reaction:R-HSA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes