Reactome | G1/S-Specific Transcription

Schema > Pathway > Entries

G1/S-Specific Transcription Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:68869] Walworth, N, O'Donnell, M, 2003-06-05
crossReference	[DatabaseIdentifier:12325450] BioModels Database:BIOMD0000000939 [DatabaseIdentifier:12325508] BioModels Database:BIOMD0000000700
dbId	69205
displayName	G1/S-Specific Transcription
eventOf	[Pathway:R-HSA-69206] G1/S Transition - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20667] G1/S transition of mitotic cell cycle
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8961620] E2F1 binds the CDC6 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961619] CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex - Homo sapiens [Reaction:R-HSA-8961636] E2F1 binds the POLA1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961632] POLA1 gene transcription is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961651] E2F1 binds the PCNA gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961665] PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex - Homo sapiens [Reaction:R-HSA-8961671] E2F1 binds the ORC1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961678] ORC1 gene expression is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961688] E2F1 binds the FBXO5 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961699] FBXO5 gene expression is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961840] E2F1 binds the CCNE1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961846] CCNE1 gene transcription is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961863] E2F1 binds the DHFR gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961874] DHFR gene expression is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961888] E2F1 binds the CCNA1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961895] CCNA1 gene expression is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961907] E2F1 binds the CDC45 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961915] CDC45 gene expression is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961920] E2F1 binds the CDK1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961934] CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 - Homo sapiens [Reaction:R-HSA-8961946] E2F1 binds the CDT1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961952] CDT1 gene expression is stimulated by E2F1 - Homo sapiens [Reaction:R-HSA-8961961] E2F1 binds the CDC25A gene promoter - Homo sapiens [Reaction:R-HSA-8961972] E2F1 binds the RRM2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961982] RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-8961991] E2F1 binds the TK1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8962039] TK1 gene expression is stimulated by E2F1 - Homo sapiens [BlackBoxEvent:R-HSA-8962050] TYMS gene expression - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:113627] Regulation of Geminin and Cdt1 expression by E2F transcription factors [LiteratureReference:141380] Cdk2-dependent and -independent pathways in E2F-mediated S phase induction [LiteratureReference:68682] Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells [LiteratureReference:113663] Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. [LiteratureReference:113626] Regulation of the cyclin E gene by transcription factor E2F1 [LiteratureReference:176432] E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1) [LiteratureReference:113660] Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor [LiteratureReference:113623] Developmental control of a G1-S transcriptional program in Drosophila [LiteratureReference:113615] Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing [LiteratureReference:113629] Functional properties of a Drosophila homolog of the E2F1 gene [LiteratureReference:113659] E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila [LiteratureReference:8961868] Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1 [LiteratureReference:8961994] G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter [LiteratureReference:8961926] The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells [LiteratureReference:8961637] Combinatorial gene control involving E2F and E Box family members [LiteratureReference:8961884] A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F [LiteratureReference:141377] CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase [LiteratureReference:8961854] Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition [LiteratureReference:8961927] E2Fs link the control of G1/S and G2/M transcription
modified	[InstanceEdit:9852745] Matthews, Lisa, 2023-11-06
name	G1/S-Specific Transcription
precedingEvent	[Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-69205
summation	[Summation:213368] The E2F family of transcription factors regulate the transit...

Referrals

(hasEvent)

[Pathway:R-HSA-69206] G1/S Transition

Cite Us!