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Schema
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Reaction
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Entries
MDM2 translocates to the nucleus
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:6793664] Orlic-Milacic, Marija, 2015-09-03
dbId
6793666
displayName
MDM2 translocates to the nucleus
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf
[Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
followingEvent
[Reaction:R-HSA-6804955] ATM phosphorylates MDM2 - Homo sapiens
[Reaction:R-HSA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Homo sapiens
[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers - Homo sapiens
[Reaction:R-HSA-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-198638] p-S166,S188-MDM2 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6793667] A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
MDM2 translocates to the nucleus
orthologousEvent
[Reaction:R-GGA-6793666] MDM2 translocates to the nucleus - Gallus gallus
[Reaction:R-XTR-6793666] MDM2 translocates to the nucleus - Xenopus tropicalis
[Reaction:R-DRE-6793666] MDM2 translocates to the nucleus - Danio rerio
[Reaction:R-SSC-6793666] MDM2 translocates to the nucleus - Sus scrofa
[Reaction:R-BTA-6793666] MDM2 translocates to the nucleus - Bos taurus
[Reaction:R-CFA-6793666] MDM2 translocates to the nucleus - Canis familiaris
[Reaction:R-RNO-6793666] MDM2 translocates to the nucleus - Rattus norvegicus
[Reaction:R-MMU-6793666] MDM2 translocates to the nucleus - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-6793669] p-S166,S188-MDM2 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-198599] AKT phosphorylates MDM2 - Homo sapiens
[Reaction:R-HSA-6795460] SGK1 phosphorylates MDM2 - Homo sapiens
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6793666
summation
[Summation:6793672] AKT- or SGK1-phosphorylated MDM2 residues S166 and S188 are ...
Referrals
(precedingEvent)
[Reaction:R-HSA-6804955] ATM phosphorylates MDM2
[Reaction:R-HSA-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2
[Reaction:R-HSA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218
[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers
(hasEvent)
[Pathway:R-HSA-6804757] Regulation of TP53 Degradation
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