Reactome | MDM2 translocates to the nucleus

Schema > Reaction > Entries

MDM2 translocates to the nucleus Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10067483
displayName	MDM2 translocates to the nucleus
eventOf	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Rattus norvegicus [Reaction:R-RNO-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Rattus norvegicus [Reaction:R-RNO-6804955] ATM phosphorylates MDM2 - Rattus norvegicus [Reaction:R-RNO-6804741] MDM2 forms homo- or heterodimers - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-198638] phospho-Mdm2 [cytosol]
isInDisease	false
isInferred	true
name	MDM2 translocates to the nucleus
output	[EntityWithAccessionedSequence:R-RNO-6793669] phospho-Mdm2 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-198599] AKT phosphorylates MDM2 - Rattus norvegicus [Reaction:R-RNO-6795460] SGK1 phosphorylates MDM2 - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6793666
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-RNO-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 [Reaction:R-RNO-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 [Reaction:R-RNO-6804955] ATM phosphorylates MDM2 [Reaction:R-RNO-6804741] MDM2 forms homo- or heterodimers
(inferredTo)	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus