Reactome | (CDK1,CDK2):CCNA phosphorylates MDM2 at T218

Schema > Reaction > Entries

(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6793658] cyclin-dependent protein serine/threonine kinase activity of CCNA:p-CDK1/2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6793660] Orlic-Milacic, Marija, 2015-09-03
dbId	6793661
displayName	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6793669] p-S166,S188-MDM2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6793662] Cyclin a-CDK phosphorylation regulates MDM2 protein interactions
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
orthologousEvent	[Reaction:R-XTR-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Xenopus tropicalis [Reaction:R-GGA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Gallus gallus [Reaction:R-DRE-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Danio rerio [Reaction:R-SSC-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Sus scrofa [Reaction:R-BTA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Bos taurus [Reaction:R-CFA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Canis familiaris [Reaction:R-RNO-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Rattus norvegicus [Reaction:R-MMU-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6792862] p-S166,S188,T218-MDM2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6793661
summation	[Summation:6793659] CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates ...

Referrals

(hasEvent)	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-HSA-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2