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MDM2 translocates to the nucleus
Stable Identifier
R-HSA-6793666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
MDM2 translocates to the nucleus (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
AKT- or SGK1-phosphorylated MDM2 residues S166 and S188 are in the vicinity of the MDM2 nuclear localization signal. MDM2 phosphorylation by AKT or SGK1 leads to MDM2 translocation from the cytosol to the nucleus (Mayo and Donner 2001).
Literature References
PubMed ID
Title
Journal
Year
11504915
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
Mayo, LD
,
Donner, DB
Proc. Natl. Acad. Sci. U.S.A.
2001
Participants
Input
p-S166,S188-MDM2 [cytosol]
(Homo sapiens)
Output
p-S166,S188-MDM2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of TP53 Degradation (Homo sapiens)
Orthologous Events
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MDM2 translocates to the nucleus (Mus musculus)
MDM2 translocates to the nucleus (Rattus norvegicus)
MDM2 translocates to the nucleus (Sus scrofa)
MDM2 translocates to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2015-10-14)
Reviewed
Zaccara, S (2016-02-04)
Inga, A (2016-02-04)
Created
Orlic-Milacic, M (2015-09-03)
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