Reactome | MDM2 translocates to the nucleus

MDM2 translocates to the nucleus

Stable Identifier

R-HSA-6793666

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        MDM2 translocates to the nucleus (Homo sapiens)

General

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AKT- or SGK1-phosphorylated MDM2 residues S166 and S188 are in the vicinity of the MDM2 nuclear localization signal. MDM2 phosphorylation by AKT or SGK1 leads to MDM2 translocation from the cytosol to the nucleus (Mayo and Donner 2001).

Literature References

PubMed ID	Title	Journal	Year
11504915	A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus Mayo, LD, Donner, DB	Proc. Natl. Acad. Sci. U.S.A.	2001