Reactome | MDM2 forms homo- or heterodimers

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MDM2 forms homo- or heterodimers Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6804733] Orlic-Milacic, Marija, 2015-10-14
dbId	6804741
displayName	MDM2 forms homo- or heterodimers
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-6804253] MDM2 ubiquitinates JMY - Homo sapiens [Reaction:R-HSA-6798373] MDM2 ubiquitinates DYRK2 - Homo sapiens [Reaction:R-HSA-349455] Phosphorylation of MDM4 by ATM - Homo sapiens [Reaction:R-HSA-6804942] MDM2 homodimers auto-ubiquitinate - Homo sapiens [Reaction:R-HSA-5633460] MDM2 binds TP53 - Homo sapiens [Reaction:R-HSA-8952371] MDM2 binds RUNX3 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-6793669] p-S166,S188-MDM2 [nucleoplasm] [DefinedSet:R-HSA-6804750] p-S166,S188-MDM2,MDM4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage [LiteratureReference:6804738] Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability [LiteratureReference:6804740] The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo [LiteratureReference:6804870] Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MDM2 forms homo- or heterodimers
orthologousEvent	[Reaction:R-GGA-6804741] MDM2 forms homo- or heterodimers - Gallus gallus [Reaction:R-XTR-6804741] MDM2 forms homo- or heterodimers - Xenopus tropicalis [Reaction:R-DRE-6804741] MDM2 forms homo- or heterodimers - Danio rerio [Reaction:R-SSC-6804741] MDM2 forms homo- or heterodimers - Sus scrofa [Reaction:R-BTA-6804741] MDM2 forms homo- or heterodimers - Bos taurus [Reaction:R-CFA-6804741] MDM2 forms homo- or heterodimers - Canis familiaris [Reaction:R-RNO-6804741] MDM2 forms homo- or heterodimers - Rattus norvegicus [Reaction:R-MMU-6804741] MDM2 forms homo- or heterodimers - Mus musculus
output	[DefinedSet:R-HSA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8979257] Negative regulation by 'p-S1981,Ac-K3016-ATM [nucleoplasm]'
regulationReference	[RegulationReference:9641470] Negative regulation by 'p-S1981,Ac-K3016-ATM [nucleoplasm]' Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6804741
summation	[Summation:6804866] To efficiently function as an E3 ubiquitin ligase, MDM2 has ...
updateTrackers	[UpdateTracker:9781785] Update Tracker - [Reaction:6804741] MDM2 forms homo- or heterodimers - v60:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9781785] Update Tracker - [Reaction:6804741] MDM2 forms homo- or heterodimers - v60:[addRegulator]
(precedingEvent)	[Reaction:R-HSA-8952371] MDM2 binds RUNX3 [Reaction:R-HSA-6804253] MDM2 ubiquitinates JMY [Reaction:R-HSA-6798373] MDM2 ubiquitinates DYRK2 [Reaction:R-HSA-349455] Phosphorylation of MDM4 by ATM [Reaction:R-HSA-6804942] MDM2 homodimers auto-ubiquitinate [Reaction:R-HSA-5633460] MDM2 binds TP53
(hasEvent)	[Pathway:R-HSA-69541] Stabilization of p53 [Pathway:R-HSA-6804757] Regulation of TP53 Degradation

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