Reactome | ATM phosphorylates MDM2

Schema > Reaction > Entries

ATM phosphorylates MDM2 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6804956] Orlic-Milacic, Marija, 2015-10-16
dbId	6804955
deleted	[Deleted:8871583] Deletion of instance: 69491
displayName	ATM phosphorylates MDM2
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6793669] p-S166,S188-MDM2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage [LiteratureReference:6804957] ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ATM phosphorylates MDM2
orthologousEvent	[Reaction:R-GGA-6804955] ATM phosphorylates MDM2 - Gallus gallus [Reaction:R-DRE-6804955] ATM phosphorylates MDM2 - Danio rerio [Reaction:R-SSC-6804955] ATM phosphorylates MDM2 - Sus scrofa [Reaction:R-BTA-6804955] ATM phosphorylates MDM2 - Bos taurus [Reaction:R-CFA-6804955] ATM phosphorylates MDM2 - Canis familiaris [Reaction:R-RNO-6804955] ATM phosphorylates MDM2 - Rattus norvegicus [Reaction:R-MMU-6804955] ATM phosphorylates MDM2 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6804954] p-5S,T-MDM2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6804955
summation	[Summation:6804962] ATM phosphorylates MDM2 on three serine residues (S386, S395...

Referrals

(replacementInstances)	[Deleted:8871583] Deletion of instance: 69491
(hasEvent)	[Pathway:R-HSA-69541] Stabilization of p53 [Pathway:R-HSA-6804757] Regulation of TP53 Degradation