Reactome | AKT phosphorylates MDM2

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AKT phosphorylates MDM2 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
dbId	198599
displayName	AKT phosphorylates MDM2
eventOf	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens [Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol - Homo sapiens
followingEvent	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172430] protein kinase B signaling
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-198644] MDM2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199351] HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation [LiteratureReference:2399962] Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation [LiteratureReference:2399963] A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein [LiteratureReference:6793667] A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	AKT phosphorylates MDM2
orthologousEvent	[Reaction:R-GGA-198599] AKT phosphorylates MDM2 - Gallus gallus [Reaction:R-DRE-198599] AKT phosphorylates MDM2 - Danio rerio [Reaction:R-RNO-198599] AKT phosphorylates MDM2 - Rattus norvegicus [Reaction:R-MMU-198599] AKT phosphorylates MDM2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-198638] p-S166,S188-MDM2 [cytosol]
precedingEvent	[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens [Reaction:R-HSA-6795667] MDM2 translocates to the cytosol - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-198599
summation	[Summation:198607] AKT phosphorylates MDM2 on two serine residues, at positions...

Referrals

(normalReaction)	[Reaction:R-HSA-2399981] AKT1 E17K mutant phosphorylates MDM2
(hasEvent)	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation [Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol
(precedingEvent)	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus