Reactome | Ub-specific processing proteases

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Ub-specific processing proteases Show undefined attributes

authored	[InstanceEdit:5688433] Jupe, Steve, 2015-04-16
created	[InstanceEdit:5689906] Jupe, Steve, 2015-04-24
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819593] BioModels Database:BIOMD0000000634
dbId	5689880
displayName	Ub-specific processing proteases
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf	[Pathway:R-HSA-5688426] Deubiquitination - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5689950] USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN - Homo sapiens [Reaction:R-HSA-5689972] USP2 deubiquitinates MDM2,MDM4 - Homo sapiens [Reaction:R-HSA-5689973] USP10,USP24,USP42 deubiquitinate TP53 - Homo sapiens [Reaction:R-HSA-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B - Homo sapiens [Reaction:R-HSA-5690157] USP16,USP21 deubiquitinate Histone H2A - Homo sapiens [Reaction:R-HSA-5690152] USP5 cleaves polyubiquitin - Homo sapiens [Reaction:R-HSA-5690196] USP8 deubiquitinates RNF128 - Homo sapiens [Reaction:R-HSA-6782628] USP8 deubiquitinates STAM2:HGS - Homo sapiens [Reaction:R-HSA-870479] USP9X (FAM) binds to ubiquitinated SMAD4 - Homo sapiens [Reaction:R-HSA-870437] USP9X (FAM) deubiquitinates SMAD4 - Homo sapiens [Reaction:R-HSA-5689539] ADRM1:26S proteaseome binds USP14 - Homo sapiens [BlackBoxEvent:R-HSA-936390] CYLD mediated deubiquitination of DDX58 (RIG-I) - Homo sapiens [Reaction:R-HSA-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Homo sapiens [Reaction:R-HSA-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Homo sapiens [Reaction:R-HSA-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Homo sapiens [Reaction:R-HSA-6782820] USP17 deubiquitinates SUDS3 - Homo sapiens [Reaction:R-HSA-5696564] USP25 deubiquitinates DDX58 - Homo sapiens [Reaction:R-HSA-5696534] USP18 deubiquitinates TAK1:TAB1 - Homo sapiens [Reaction:R-HSA-6782106] USP10 deubiquitinates SNX3, CFTR - Homo sapiens [Reaction:R-HSA-5696605] USP12, USP26 deubiquitinate AR - Homo sapiens [Reaction:R-HSA-6781897] USP11 deubiquitinates NFKBIA - Homo sapiens [Reaction:R-HSA-6781899] USP13 binds SIAH2 - Homo sapiens [Reaction:R-HSA-6781922] USP13 binds UFD1L:SKP2 - Homo sapiens [Reaction:R-HSA-6781779] USP13 deubiquitinates BECN1,USP10 - Homo sapiens [Reaction:R-HSA-6781814] USP19 deubiquitinates RNF123 - Homo sapiens [Reaction:R-HSA-6781797] USP19 binds HIF1A,BIRC2,BIRC3 - Homo sapiens [Reaction:R-HSA-5696968] USP20, USP33 deubiquitinate ADRB2 - Homo sapiens [Reaction:R-HSA-5690159] USP21 deubiquitinates RIPK1,DDX58 - Homo sapiens [Reaction:R-HSA-6783177] USP21 deubiquitinates GATA3,IL33 - Homo sapiens [Reaction:R-HSA-5696997] USP24 deubiquitinates DDB2 - Homo sapiens [Reaction:R-HSA-5696914] USP28 deubiquitinates CLSPN and MYC - Homo sapiens [Reaction:R-HSA-5696872] USP30 deubiquitinates Ub-MOM proteins - Homo sapiens [Reaction:R-HSA-5696945] USP33 deubiquitinates CCP110,ARRB - Homo sapiens [Reaction:R-HSA-3640872] USP34 deubiquitinates AXIN1,AXIN2 - Homo sapiens [Reaction:R-HSA-5697009] USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 - Homo sapiens [Reaction:R-HSA-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Homo sapiens [Reaction:R-HSA-5696958] USP44 deubiquitinates CDC20 - Homo sapiens [Reaction:R-HSA-5696947] USP47 deubiquitinates POLB - Homo sapiens [Reaction:R-HSA-5696960] USP49 deubiquitinates H2B - Homo sapiens [BlackBoxEvent:R-HSA-8862184] USP48 cleaves polyubiquitin - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:5689914] A genomic and functional inventory of deubiquitinating enzymes
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Ub-specific processing proteases
orthologousEvent	[Pathway:R-PFA-5689880] Ub-specific processing proteases - Plasmodium falciparum [Pathway:R-SCE-5689880] Ub-specific processing proteases - Saccharomyces cerevisiae [Pathway:R-SPO-5689880] Ub-specific processing proteases - Schizosaccharomyces pombe [Pathway:R-DDI-5689880] Ub-specific processing proteases - Dictyostelium discoideum [Pathway:R-CEL-5689880] Ub-specific processing proteases - Caenorhabditis elegans [Pathway:R-DME-5689880] Ub-specific processing proteases - Drosophila melanogaster [Pathway:R-GGA-5689880] Ub-specific processing proteases - Gallus gallus [Pathway:R-MMU-5689880] Ub-specific processing proteases - Mus musculus [Pathway:R-RNO-5689880] Ub-specific processing proteases - Rattus norvegicus [Pathway:R-CFA-5689880] Ub-specific processing proteases - Canis familiaris [Pathway:R-BTA-5689880] Ub-specific processing proteases - Bos taurus [Pathway:R-SSC-5689880] Ub-specific processing proteases - Sus scrofa [Pathway:R-DRE-5689880] Ub-specific processing proteases - Danio rerio [Pathway:R-XTR-5689880] Ub-specific processing proteases - Xenopus tropicalis
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5689880
summation	[Summation:5689886] Ub-specific processing proteases (USPs) are the largest of t...
updateTrackers	[UpdateTracker:9777854] Update Tracker - [Pathway:5689880] Ub-specific processing proteases - v68:[updateContainedRLE] [UpdateTracker:9774652] Update Tracker - [Pathway:5689880] Ub-specific processing proteases - v81:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5688426] Deubiquitination
(updatedInstance)	[UpdateTracker:9777854] Update Tracker - [Pathway:5689880] Ub-specific processing proteases - v68:[updateContainedRLE] [UpdateTracker:9774652] Update Tracker - [Pathway:5689880] Ub-specific processing proteases - v81:[updateContainedRLE]

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