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Schema
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Reaction
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Entries
USP4 deubiquitinate TRAF2,TRAF6
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authored
[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity
[CatalystActivity:8869453] cysteine-type deubiquitinase activity of USP4 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:8869459] Jupe, Steve, 2016-05-04
dbId
8869456
displayName
USP4 deubiquitinate TRAF2,TRAF6
edited
[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf
[Pathway:R-HSA-5689880] Ub-specific processing proteases - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[Complex:R-HSA-8869451] USP4:PolyUb-TRAF2, PolyUb-TRAF6 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5696903] Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF?-induced cancer cell migration
maxDepth
1
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
USP4 deubiquitinate TRAF2,TRAF6
orthologousEvent
[Reaction:R-DDI-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Dictyostelium discoideum
[Reaction:R-GGA-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Gallus gallus
[Reaction:R-XTR-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Xenopus tropicalis
[Reaction:R-DRE-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Danio rerio
[Reaction:R-SSC-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Sus scrofa
[Reaction:R-BTA-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Bos taurus
[Reaction:R-CFA-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Canis familiaris
[Reaction:R-RNO-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Rattus norvegicus
[Reaction:R-MMU-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Mus musculus
output
[DefinedSet:R-HSA-5689096] PolyUb [cytosol]
[DefinedSet:R-HSA-918188] TRAF2, TRAF6 [cytosol]
releaseDate
2016-06-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8869456
summation
[Summation:5696506] USP4 specifically interacts with tumor necrosis factor (TNF)...
Referrals
(hasEvent)
[Pathway:R-HSA-5689880] Ub-specific processing proteases
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