Reactome | Ub-specific processing proteases

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Ub-specific processing proteases Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557525
displayName	Ub-specific processing proteases
eventOf	[Pathway:R-SSC-5688426] Deubiquitination - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-5689950] USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN - Sus scrofa [Reaction:R-SSC-5689973] USP10,USP24,USP42 deubiquitinate TP53 - Sus scrofa [Reaction:R-SSC-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B - Sus scrofa [Reaction:R-SSC-5690157] USP16,USP21 deubiquitinate Histone H2A - Sus scrofa [Reaction:R-SSC-5690152] USP5 cleaves polyubiquitin - Sus scrofa [Reaction:R-SSC-5690196] USP8 deubiquitinates RNF128 - Sus scrofa [Reaction:R-SSC-6782628] USP8 deubiquitinates STAM2:HGS - Sus scrofa [Reaction:R-SSC-870479] USP9X (FAM) binds to ubiquitinated SMAD4 - Sus scrofa [Reaction:R-SSC-870437] USP9X (FAM) deubiquitinates SMAD4 - Sus scrofa [Reaction:R-SSC-5689539] ADRM1:26S proteaseome binds USP14 - Sus scrofa [BlackBoxEvent:R-SSC-936390] CYLD mediated deubiquitination of DDX58 (RIG-I) - Sus scrofa [Reaction:R-SSC-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Sus scrofa [Reaction:R-SSC-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Sus scrofa [Reaction:R-SSC-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Sus scrofa [Reaction:R-SSC-6782820] USP17 deubiquitinates SUDS3 - Sus scrofa [Reaction:R-SSC-5696564] USP25 deubiquitinates DDX58 - Sus scrofa [Reaction:R-SSC-5696534] USP18 deubiquitinates TAK1:TAB1 - Sus scrofa [Reaction:R-SSC-6782106] USP10 deubiquitinates SNX3, CFTR - Sus scrofa [Reaction:R-SSC-5696605] USP12, USP26 deubiquitinate AR - Sus scrofa [Reaction:R-SSC-6781897] USP11 deubiquitinates NFKBIA - Sus scrofa [Reaction:R-SSC-6781899] USP13 binds SIAH2 - Sus scrofa [Reaction:R-SSC-6781922] USP13 binds UFD1L:SKP2 - Sus scrofa [Reaction:R-SSC-6781779] USP13 deubiquitinates BECN1,USP10 - Sus scrofa [Reaction:R-SSC-6781814] USP19 deubiquitinates RNF123 - Sus scrofa [Reaction:R-SSC-6781797] USP19 binds HIF1A,BIRC2,BIRC3 - Sus scrofa [Reaction:R-SSC-5696968] USP20, USP33 deubiquitinate ADRB2 - Sus scrofa [Reaction:R-SSC-5690159] USP21 deubiquitinates RIPK1,DDX58 - Sus scrofa [Reaction:R-SSC-6783177] USP21 deubiquitinates GATA3,IL33 - Sus scrofa [Reaction:R-SSC-5696997] USP24 deubiquitinates DDB2 - Sus scrofa [Reaction:R-SSC-5696914] USP28 deubiquitinates CLSPN and MYC - Sus scrofa [Reaction:R-SSC-5696872] USP30 deubiquitinates Ub-MOM proteins - Sus scrofa [Reaction:R-SSC-5696945] USP33 deubiquitinates CCP110,ARRB - Sus scrofa [Reaction:R-SSC-5697009] USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 - Sus scrofa [Reaction:R-SSC-8869456] USP4 deubiquitinate TRAF2,TRAF6 - Sus scrofa [Reaction:R-SSC-5696958] USP44 deubiquitinates CDC20 - Sus scrofa [Reaction:R-SSC-5696947] USP47 deubiquitinates POLB - Sus scrofa [BlackBoxEvent:R-SSC-8862184] USP48 cleaves polyubiquitin - Sus scrofa
inferredFrom	[Pathway:R-HSA-5689880] Ub-specific processing proteases - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Ub-specific processing proteases
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-5689880
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5688426] Deubiquitination
(inferredTo)	[Pathway:R-HSA-5689880] Ub-specific processing proteases

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