Reactome | USP21 deubiquitinates RIPK1,DDX58

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USP21 deubiquitinates RIPK1,DDX58 Show undefined attributes

authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:5690095] cysteine-type deubiquitinase activity of USP21:PolyUb-RIPK1, PolyUb-DDX58 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5690100] Jupe, Steve, 2015-04-27
dbId	5690159
displayName	USP21 deubiquitinates RIPK1,DDX58
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf	[Pathway:R-HSA-5689880] Ub-specific processing proteases - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-6783163] USP21:PolyUb-RIPK1, PolyUb-DDX58 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690205] USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase [LiteratureReference:5357906] Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	USP21 deubiquitinates RIPK1,DDX58
orthologousEvent	[Reaction:R-PFA-5690159] USP21 deubiquitinates RIPK1,DDX58 - Plasmodium falciparum [Reaction:R-DDI-5690159] USP21 deubiquitinates RIPK1,DDX58 - Dictyostelium discoideum [Reaction:R-CEL-5690159] USP21 deubiquitinates RIPK1,DDX58 - Caenorhabditis elegans [Reaction:R-DME-5690159] USP21 deubiquitinates RIPK1,DDX58 - Drosophila melanogaster [Reaction:R-XTR-5690159] USP21 deubiquitinates RIPK1,DDX58 - Xenopus tropicalis [Reaction:R-SSC-5690159] USP21 deubiquitinates RIPK1,DDX58 - Sus scrofa [Reaction:R-BTA-5690159] USP21 deubiquitinates RIPK1,DDX58 - Bos taurus [Reaction:R-CFA-5690159] USP21 deubiquitinates RIPK1,DDX58 - Canis familiaris [Reaction:R-RNO-5690159] USP21 deubiquitinates RIPK1,DDX58 - Rattus norvegicus [Reaction:R-MMU-5690159] USP21 deubiquitinates RIPK1,DDX58 - Mus musculus
output	[DefinedSet:R-HSA-5689096] PolyUb [cytosol] [Complex:R-HSA-6783081] USP21:RIPK1,DDX58 [cytosol]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690159
summation	[Summation:5690092] USP21 is not required for normal development (Pannu et al. 2...

Referrals

(hasEvent)

[Pathway:R-HSA-5689880] Ub-specific processing proteases