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Schema
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Reaction
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Entries
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
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authored
[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity
[CatalystActivity:5696921] cysteine-type deubiquitinase activity of CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5696617] Jupe, Steve, 2015-05-29
dbId
5696627
displayName
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
edited
[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf
[Pathway:R-HSA-5689880] Ub-specific processing proteases - Homo sapiens
input
[Complex:R-HSA-6782801] CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:741393] The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
[LiteratureReference:6782814] CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
[LiteratureReference:6782816] Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
orthologousEvent
[Reaction:R-PFA-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Plasmodium falciparum
[Reaction:R-DDI-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Dictyostelium discoideum
[Reaction:R-DME-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Drosophila melanogaster
[Reaction:R-GGA-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Gallus gallus
[Reaction:R-DRE-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Danio rerio
[Reaction:R-SSC-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Sus scrofa
[Reaction:R-BTA-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Bos taurus
[Reaction:R-CFA-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Canis familiaris
[Reaction:R-RNO-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Rattus norvegicus
[Reaction:R-MMU-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Mus musculus
output
[Polymer:R-HSA-450152] K63polyUb [cytosol]
[DefinedSet:R-HSA-6782832] TRAF2,TRAF6,IKBKG,RIPK1 [cytosol]
releaseDate
2016-06-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5696627
summation
[Summation:5696556] CYLD removes Lys63-linked ubiquitin chains, acting as a nega...
Referrals
(hasEvent)
[Pathway:R-HSA-5689880] Ub-specific processing proteases
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