Reactome | USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1

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USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 Show undefined attributes

authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:5696893] cysteine-type deubiquitinase activity of USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5696617] Jupe, Steve, 2015-05-29
dbId	5696600
displayName	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf	[Pathway:R-HSA-5689880] Ub-specific processing proteases - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-6782800] USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5696895] USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity [LiteratureReference:5696910] Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A [LiteratureReference:5696857] The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
orthologousEvent	[Reaction:R-SCE-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Saccharomyces cerevisiae [Reaction:R-SPO-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Schizosaccharomyces pombe [Reaction:R-DDI-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Dictyostelium discoideum [Reaction:R-CEL-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Caenorhabditis elegans [Reaction:R-DME-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Drosophila melanogaster [Reaction:R-XTR-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Xenopus tropicalis [Reaction:R-DRE-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Danio rerio [Reaction:R-SSC-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Sus scrofa [Reaction:R-BTA-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Bos taurus [Reaction:R-CFA-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Canis familiaris [Reaction:R-RNO-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Rattus norvegicus [Reaction:R-MMU-5696600] USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 - Mus musculus
output	[DefinedSet:R-HSA-5689096] PolyUb [cytosol] [Complex:R-HSA-6782822] USP17L1,USP17L2:RCE1, CDC25A, DDX58, IFIH1 [cytosol]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5696600
summation	[Summation:5696607] USP17 regulates cell proliferation by deubiquitinating and i...

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[Pathway:R-HSA-5689880] Ub-specific processing proteases