Reactome | USP13 deubiquitinates BECN1,USP10

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USP13 deubiquitinates BECN1,USP10 Show undefined attributes

authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:6782975] cysteine-type deubiquitinase activity of USP13:K63polyUb-BECN1,K63polyUb-USP10 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6781793] Jupe, Steve, 2015-06-02
dbId	6781779
displayName	USP13 deubiquitinates BECN1,USP10
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf	[Pathway:R-HSA-5689880] Ub-specific processing proteases - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-6782957] USP13:K63polyUb-BECN1,K63polyUb-USP10 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6781949] Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13 [LiteratureReference:6781907] Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin
modified	[InstanceEdit:10871105] Wright, Adam, 2024-03-08
name	USP13 deubiquitinates BECN1,USP10
orthologousEvent	[Reaction:R-SPO-6781779] USP13 deubiquitinates BECN1,USP10 - Schizosaccharomyces pombe [Reaction:R-DDI-6781779] USP13 deubiquitinates BECN1,USP10 - Dictyostelium discoideum [Reaction:R-DME-6781779] USP13 deubiquitinates BECN1,USP10 - Drosophila melanogaster [Reaction:R-GGA-6781779] USP13 deubiquitinates BECN1,USP10 - Gallus gallus [Reaction:R-DRE-6781779] USP13 deubiquitinates BECN1,USP10 - Danio rerio [Reaction:R-SSC-6781779] USP13 deubiquitinates BECN1,USP10 - Sus scrofa [Reaction:R-BTA-6781779] USP13 deubiquitinates BECN1,USP10 - Bos taurus [Reaction:R-CFA-6781779] USP13 deubiquitinates BECN1,USP10 - Canis familiaris [Reaction:R-RNO-6781779] USP13 deubiquitinates BECN1,USP10 - Rattus norvegicus [Reaction:R-MMU-6781779] USP13 deubiquitinates BECN1,USP10 - Mus musculus
output	[Polymer:R-HSA-450152] K63polyUb [cytosol] [Complex:R-HSA-6782992] USP13:BECN1,USP10 [cytosol]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6781779
summation	[Summation:6781801] USP13 preferentially cleaves Lys-63-linked polyubiquitin cha...

Referrals

(hasEvent)

[Pathway:R-HSA-5689880] Ub-specific processing proteases