Reactome | USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1

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USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 Show undefined attributes

authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:6781799] cysteine-type deubiquitinase activity of USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6781793] Jupe, Steve, 2015-06-02
dbId	6781764
displayName	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
eventOf	[Pathway:R-HSA-5689880] Ub-specific processing proteases - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-6782777] USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6781781] Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
orthologousEvent	[Reaction:R-CEL-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Caenorhabditis elegans [Reaction:R-DME-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Drosophila melanogaster [Reaction:R-GGA-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Gallus gallus [Reaction:R-XTR-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Xenopus tropicalis [Reaction:R-DRE-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Danio rerio [Reaction:R-SSC-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Sus scrofa [Reaction:R-BTA-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Bos taurus [Reaction:R-CFA-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Canis familiaris [Reaction:R-RNO-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Rattus norvegicus [Reaction:R-MMU-6781764] USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 - Mus musculus
output	3 × [DefinedSet:R-HSA-113595] Ub [cytosol] [Complex:R-HSA-6782802] USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6781764
summation	[Summation:6781761] USP15 is a ubiquitin-specific protease (Baker et al. 1999) r...

Referrals

(hasEvent)

[Pathway:R-HSA-5689880] Ub-specific processing proteases