Reactome | PP2A dephosphorylates inactive RAFs

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PP2A dephosphorylates inactive RAFs Show undefined attributes

authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
catalystActivity	[CatalystActivity:5672955] protein serine/threonine phosphatase activity of PP2A [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5672959] Rothfels, Karen, 2015-02-06
dbId	5672961
displayName	PP2A dephosphorylates inactive RAFs
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-5672707] inactive RAFs:YWHAB dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5672521] Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase [LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites [LiteratureReference:208163] Dephosphorylation of Ser-259 regulates Raf-1 membrane association [LiteratureReference:208364] Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions [LiteratureReference:5672416] Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1 [LiteratureReference:5672517] RAF protein-serine/threonine kinases: structure and regulation [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5672478] Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation [LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization [LiteratureReference:5672425] Active Ras induces heterodimerization of cRaf and BRaf [LiteratureReference:5672454] Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling [LiteratureReference:5674056] Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration [LiteratureReference:5674053] Ras-Raf signaling needs prohibitin [LiteratureReference:5674049] Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PP2A dephosphorylates inactive RAFs
orthologousEvent	[Reaction:R-CEL-5672961] PP2A dephosphorylates inactive RAFs - Caenorhabditis elegans [Reaction:R-DME-5672961] PP2A dephosphorylates inactive RAFs - Drosophila melanogaster [Reaction:R-XTR-5672961] PP2A dephosphorylates inactive RAFs - Xenopus tropicalis [Reaction:R-SSC-5672961] PP2A dephosphorylates inactive RAFs - Sus scrofa [Reaction:R-BTA-5672961] PP2A dephosphorylates inactive RAFs - Bos taurus [Reaction:R-RNO-5672961] PP2A dephosphorylates inactive RAFs - Rattus norvegicus [Reaction:R-MMU-5672961] PP2A dephosphorylates inactive RAFs - Mus musculus
output	[Complex:R-HSA-5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-5672951] Inactive RAFs bind YWHAB - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672961
summation	[Summation:5672627] Upon growth factor stimulation, RAF1 S259 (or S365 and S214 ...

Referrals

(hasEvent)	[Pathway:R-HSA-5673000] RAF activation
(precedingEvent)	[Reaction:R-HSA-5672960] YWHAB dimer dissociates from dephosphorylated RAF

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