Reactome | YWHAB dimer dissociates from dephosphorylated RAF

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YWHAB dimer dissociates from dephosphorylated RAF Show undefined attributes

authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5672959] Rothfels, Karen, 2015-02-06
dbId	5672960
deleted	[Deleted:6798801] Deletion of instance: 109803
displayName	YWHAB dimer dissociates from dephosphorylated RAF
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
input	[Complex:R-HSA-5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites [LiteratureReference:208364] Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions [LiteratureReference:5672416] Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1 [LiteratureReference:5672264] Ras signaling: PP2A puts Ksr and Raf in the right place [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5674056] Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration [LiteratureReference:5674049] Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway [LiteratureReference:5674053] Ras-Raf signaling needs prohibitin
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	YWHAB dimer dissociates from dephosphorylated RAF
orthologousEvent	[Reaction:R-PFA-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Plasmodium falciparum [Reaction:R-CEL-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Caenorhabditis elegans [Reaction:R-DME-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Drosophila melanogaster [Reaction:R-GGA-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Gallus gallus [Reaction:R-XTR-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Xenopus tropicalis [Reaction:R-DRE-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Danio rerio [Reaction:R-SSC-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Sus scrofa [Reaction:R-BTA-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Bos taurus [Reaction:R-RNO-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Rattus norvegicus [Reaction:R-MMU-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Mus musculus
output	[DefinedSet:R-HSA-5672726] dephosphorylated inactive RAFs [cytosol] [Complex:R-HSA-2028645] YWHAB dimer [cytosol]
precedingEvent	[Reaction:R-HSA-5672961] PP2A dephosphorylates inactive RAFs - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672960
summation	[Summation:5672609] Dephosphorylation of S259 (S365/S214) by PP2A promotes the t...

Referrals

(replacementInstances)	[Deleted:6798801] Deletion of instance: 109803
(hasEvent)	[Pathway:R-HSA-5673000] RAF activation