Reactome | YWHAB dimer dissociates from KSR1:MARK3

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YWHAB dimer dissociates from KSR1:MARK3 Show undefined attributes

authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5672956] Rothfels, Karen, 2015-02-06
dbId	5672958
displayName	YWHAB dimer dissociates from KSR1:MARK3
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Homo sapiens
input	[Complex:R-HSA-5672692] p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208393] C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 [LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites [LiteratureReference:5672264] Ras signaling: PP2A puts Ksr and Raf in the right place
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	YWHAB dimer dissociates from KSR1:MARK3
orthologousEvent	[Reaction:R-PFA-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Plasmodium falciparum [Reaction:R-CEL-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Caenorhabditis elegans [Reaction:R-DME-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Drosophila melanogaster [Reaction:R-GGA-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Gallus gallus [Reaction:R-SSC-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Sus scrofa [Reaction:R-BTA-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Bos taurus [Reaction:R-RNO-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Rattus norvegicus [Reaction:R-MMU-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Mus musculus
output	[Complex:R-HSA-5672691] p-S311 KSR1:MARK3 [cytosol] [Complex:R-HSA-2028645] YWHAB dimer [cytosol]
precedingEvent	[Reaction:R-HSA-5672957] PP2A dephosphorylates KSR1 - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672958
summation	[Summation:5672607] Dephosphorylation of KSR1 S406 by PP2A promotes the dissocia...

Referrals

(hasEvent)	[Pathway:R-HSA-5673000] RAF activation
(precedingEvent)	[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers