Reactome | p-S311,S406 KSR1:MARK3 binds YWHAB dimer

Schema > Reaction > Entries

p-S311,S406 KSR1:MARK3 binds YWHAB dimer Show undefined attributes

authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5672953] Rothfels, Karen, 2015-02-06
dbId	5672954
displayName	p-S311,S406 KSR1:MARK3 binds YWHAB dimer
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5672957] PP2A dephosphorylates KSR1 - Homo sapiens
input	[Complex:R-HSA-5672695] p-S311,S406 KSR1:MARK3 [cytosol] [Complex:R-HSA-2028645] YWHAB dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5672264] Ras signaling: PP2A puts Ksr and Raf in the right place [LiteratureReference:208393] C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 [LiteratureReference:208057] Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling [LiteratureReference:208164] Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	p-S311,S406 KSR1:MARK3 binds YWHAB dimer
orthologousEvent	[Reaction:R-PFA-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Plasmodium falciparum [Reaction:R-CEL-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Caenorhabditis elegans [Reaction:R-DME-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Drosophila melanogaster [Reaction:R-GGA-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Gallus gallus [Reaction:R-SSC-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Sus scrofa [Reaction:R-BTA-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Bos taurus [Reaction:R-RNO-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Rattus norvegicus [Reaction:R-MMU-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Mus musculus
output	[Complex:R-HSA-5672696] p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol]
precedingEvent	[Reaction:R-HSA-5672948] MARK3 phosphorylates KSR1 - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672954
summation	[Summation:5672618] MARK3-mediated phosphorylation of S311 and particularly S406...

Referrals

(hasEvent)	[Pathway:R-HSA-5673000] RAF activation
(precedingEvent)	[Reaction:R-HSA-5672957] PP2A dephosphorylates KSR1