Reactome | MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs

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MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
catalystActivity	[CatalystActivity:9658443] protein serine/threonine phosphatase activity of S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9658450] Rothfels, Karen, 2019-08-14
dbId	9658445
displayName	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
eventOf	[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-5672707] inactive RAFs:YWHAB dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:208163] Dephosphorylation of Ser-259 regulates Raf-1 membrane association [LiteratureReference:5672478] Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation [LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites [LiteratureReference:9660339] A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity [LiteratureReference:9660364] An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth [LiteratureReference:9654499] RAS Proteins and Their Regulators in Human Disease [LiteratureReference:9660412] Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair [LiteratureReference:9660335] A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair [LiteratureReference:9660390] Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy [LiteratureReference:5674056] Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration [LiteratureReference:5674053] Ras-Raf signaling needs prohibitin [LiteratureReference:5674049] Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
orthologousEvent	[Reaction:R-CEL-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Caenorhabditis elegans [Reaction:R-GGA-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Gallus gallus [Reaction:R-DRE-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Danio rerio [Reaction:R-SSC-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Sus scrofa [Reaction:R-BTA-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Bos taurus [Reaction:R-RNO-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Rattus norvegicus [Reaction:R-MMU-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Mus musculus
output	[Complex:R-HSA-5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-5672951] Inactive RAFs bind YWHAB - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9658445
summation	[Summation:9660453] Activation of RAF upon growth factor stimulation depends on ...

Referrals

(normalReaction)	[Reaction:R-HSA-9660538] Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs [FailedReaction:R-HSA-9660536] SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex
(hasEvent)	[Pathway:R-HSA-5673000] RAF activation

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