Reactome | PP2A dephosphorylates KSR1

Schema > Reaction > Entries

PP2A dephosphorylates KSR1 Show undefined attributes

authored	[InstanceEdit:5673005] Rothfels, Karen, 2015-02-06
catalystActivity	[CatalystActivity:5672955] protein serine/threonine phosphatase activity of PP2A [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5672956] Rothfels, Karen, 2015-02-06
dbId	5672957
displayName	PP2A dephosphorylates KSR1
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-5672696] p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites [LiteratureReference:208393] C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 [LiteratureReference:5672264] Ras signaling: PP2A puts Ksr and Raf in the right place
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PP2A dephosphorylates KSR1
orthologousEvent	[Reaction:R-CEL-5672957] PP2A dephosphorylates KSR1 - Caenorhabditis elegans [Reaction:R-DME-5672957] PP2A dephosphorylates KSR1 - Drosophila melanogaster [Reaction:R-SSC-5672957] PP2A dephosphorylates KSR1 - Sus scrofa [Reaction:R-BTA-5672957] PP2A dephosphorylates KSR1 - Bos taurus [Reaction:R-RNO-5672957] PP2A dephosphorylates KSR1 - Rattus norvegicus [Reaction:R-MMU-5672957] PP2A dephosphorylates KSR1 - Mus musculus
output	[Complex:R-HSA-5672692] p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672957
summation	[Summation:5672625] Upon growth factor stimulation, KSR1 is dephosphorylated at ...

Referrals

(hasEvent)	[Pathway:R-HSA-5673000] RAF activation
(precedingEvent)	[Reaction:R-HSA-5672958] YWHAB dimer dissociates from KSR1:MARK3