Reactome | RAF activation

Schema > Pathway > Entries

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730872
displayName	RAF activation
eventOf	[Pathway:R-XTR-5673001] RAF/MAP kinase cascade - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-5672951] Inactive RAFs bind YWHAB - Xenopus tropicalis [Reaction:R-XTR-5672961] PP2A dephosphorylates inactive RAFs - Xenopus tropicalis [Reaction:R-XTR-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RAF activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5673000
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-5673000] RAF activation