Reactome | RHOA:GTP [plasma membrane]

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RHOA:GTP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9013010] RHOA:GTP:cytosolic RHOA effectors [plasma membrane] - Homo sapiens [Complex:R-HSA-3928564] RHOA:GTP:ROCK1,ROCK2 [plasma membrane] - Homo sapiens [Complex:R-HSA-2134514] Tight Junction Complex:PARD6A:RHOA [cell junction] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8981637] RHOA GAPs stimulate RHOA GTPase activity - Homo sapiens [Reaction:R-HSA-9013009] RHOA binds effectors at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-9013006] RHOA:GTP translocates to the ER membrane - Homo sapiens [Reaction:R-HSA-5667008] RHOA:GTP binds RHPN1 or RHPN2 - Homo sapiens [Reaction:R-HSA-8985594] MYO9B inactivates RHOA - Homo sapiens [Reaction:R-HSA-416559] Inactivation of Rho-GTP by p190RhoGAP - Homo sapiens [Reaction:R-HSA-5665989] DIAPH1 binds RHOA:GTP - Homo sapiens [Reaction:R-HSA-3928576] RHOA:GTP binds ROCK, activating it - Homo sapiens [Reaction:R-HSA-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Homo sapiens [Reaction:R-HSA-8849085] ARHGAP35 binds RHOA:GTP - Homo sapiens
created	[InstanceEdit:5665990] Orlic-Milacic, Marija, 2015-01-20
dbId	5665993
displayName	RHOA:GTP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29438] GTP [cytosol] [EntityWithAccessionedSequence:R-HSA-194510] RHOA [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-5667053] RhoA:GTP [plasma membrane] - Mus musculus [Complex:R-RNO-5665993] RHOA:GTP [plasma membrane] - Rattus norvegicus [Complex:R-CFA-5665993] RHOA:GTP [plasma membrane] - Canis familiaris [Complex:R-BTA-5665993] RHOA:GTP [plasma membrane] - Bos taurus [Complex:R-SSC-5665993] RHOA:GTP [plasma membrane] - Sus scrofa [Complex:R-DRE-5665993] RHOA:GTP [plasma membrane] - Danio rerio [Complex:R-XTR-5665993] RHOA:GTP [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-5665993] RHOA:GTP [plasma membrane] - Gallus gallus [Complex:R-DME-5665993] RHOA:GTP [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-5665993] RHOA:GTP [plasma membrane] - Caenorhabditis elegans [Complex:R-SPO-5665993] RHOA:GTP [plasma membrane] - Schizosaccharomyces pombe [Complex:R-SCE-5665993] RHOA:GTP [plasma membrane] - Saccharomyces cerevisiae
isChimeric	false
maxDepth	2
memberOf	[DefinedSet:R-HSA-8981458] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] - Homo sapiens
name	RHOA:GTP
producedByEvent	[Reaction:R-HSA-8980691] RHOA GEFs activate RHOA - Homo sapiens [Reaction:R-HSA-114544] p115-RhoGEF activation of RHOA - Homo sapiens [Reaction:R-HSA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Homo sapiens [Reaction:R-HSA-3928651] NGEF exchanges GTP for GDP on RHOA - Homo sapiens [Reaction:R-HSA-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5665993

Referrals

(input)	[Reaction:R-HSA-8981637] RHOA GAPs stimulate RHOA GTPase activity [Reaction:R-HSA-9013009] RHOA binds effectors at the plasma membrane [BlackBoxEvent:R-HSA-9013006] RHOA:GTP translocates to the ER membrane [Reaction:R-HSA-5667008] RHOA:GTP binds RHPN1 or RHPN2 [Reaction:R-HSA-8985594] MYO9B inactivates RHOA [Reaction:R-HSA-3928576] RHOA:GTP binds ROCK, activating it [Reaction:R-HSA-416559] Inactivation of Rho-GTP by p190RhoGAP [Reaction:R-HSA-5665989] DIAPH1 binds RHOA:GTP [Reaction:R-HSA-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 [Reaction:R-HSA-8849085] ARHGAP35 binds RHOA:GTP
(hasComponent)	[Complex:R-HSA-9013010] RHOA:GTP:cytosolic RHOA effectors [plasma membrane] [Complex:R-HSA-5667060] RHOA:GTP:RHPN1 [plasma membrane] [Complex:R-HSA-5667010] RHOA:GTP:RHPN1,RHPN2 [plasma membrane] [Complex:R-HSA-5666198] RHOA:GTP:RTKN:LIN7B [plasma membrane] [Complex:R-HSA-5666199] RHOA:GTP:RTKN [plasma membrane] [Complex:R-HSA-5665988] RHOA:GTP:DIAPH1 [plasma membrane] [Complex:R-HSA-3928564] RHOA:GTP:ROCK1,ROCK2 [plasma membrane] [Complex:R-HSA-8849072] p-Y1105-ARHGAP35:RHOA:GTP [cytosol] [Complex:R-HSA-2134514] Tight Junction Complex:PARD6A:RHOA [cell junction]
(output)	[Reaction:R-HSA-8980691] RHOA GEFs activate RHOA [Reaction:R-HSA-114544] p115-RhoGEF activation of RHOA [Reaction:R-HSA-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it [Reaction:R-HSA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth [Reaction:R-HSA-3928651] NGEF exchanges GTP for GDP on RHOA
(hasMember)	[DefinedSet:R-HSA-8981458] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane]

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