Reactome | RHOA GEFs activate RHOA

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RHOA GEFs activate RHOA Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:8980695] guanyl-nucleotide exchange factor activity of RHOA GEFs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8980689] Orlic-Milacic, Marija, 2017-02-28
dbId	8980691
deleted	[Deleted:9768327] Deletion of instance: 194913
displayName	RHOA GEFs activate RHOA
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-8980692] RHOA GTPase cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-8981637] RHOA GAPs stimulate RHOA GTPase activity - Homo sapiens [Reaction:R-HSA-9013009] RHOA binds effectors at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-9013006] RHOA:GTP translocates to the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-8964174] RHOA:GDP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8980785] Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family [LiteratureReference:8980798] Direct involvement of the small GTP-binding protein Rho in lbc oncogene function [LiteratureReference:196525] Identification of a novel guanine nucleotide exchange factor for the Rho GTPase [LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:8980733] Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) [LiteratureReference:9644678] SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines [LiteratureReference:8980813] Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10 [LiteratureReference:8980821] Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture [LiteratureReference:8980715] GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor [LiteratureReference:8980716] Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member [LiteratureReference:8980765] Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA [LiteratureReference:8980713] ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells [LiteratureReference:8980711] A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain [LiteratureReference:8980712] Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4 [LiteratureReference:8964157] G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production [LiteratureReference:8964153] Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor [LiteratureReference:8980754] WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney [LiteratureReference:8980770] Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton [LiteratureReference:8980771] Divergence of Rho residue 43 impacts GEF activity [LiteratureReference:8980724] The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle [LiteratureReference:8980718] Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors [LiteratureReference:8980796] Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes [LiteratureReference:8980756] Scambio, a novel guanine nucleotide exchange factor for Rho [LiteratureReference:8980793] Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis [LiteratureReference:8980763] XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC [LiteratureReference:8980748] Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation [LiteratureReference:8980850] A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype [LiteratureReference:8980827] The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3 [LiteratureReference:8980826] Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1 [LiteratureReference:8980833] TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner [LiteratureReference:8980837] Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 [LiteratureReference:375880] The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains [LiteratureReference:8980819] Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation [LiteratureReference:442697] PAK kinases are directly coupled to the PIX family of nucleotide exchange factors [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:3928204] Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules [LiteratureReference:5229003] Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2 [LiteratureReference:9644429] Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins [LiteratureReference:9679362] Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 cells [LiteratureReference:9679365] Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases [LiteratureReference:9644555] Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration [LiteratureReference:9644565] A role for Rac in Tiam1-induced membrane ruffling and invasion [LiteratureReference:9644570] Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering [LiteratureReference:9679380] Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1 [LiteratureReference:9691488] DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA [LiteratureReference:9714239] Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions [LiteratureReference:9716753] Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology [LiteratureReference:434852] Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RHOA GEFs activate RHOA
orthologousEvent	[Reaction:R-CEL-8980691] RHOA GEFs activate RHOA - Caenorhabditis elegans [Reaction:R-DME-8980691] RHOA GEFs activate RHOA - Drosophila melanogaster [Reaction:R-GGA-8980691] RHOA GEFs activate RHOA - Gallus gallus [Reaction:R-XTR-8980691] RHOA GEFs activate RHOA - Xenopus tropicalis [Reaction:R-DRE-8980691] RHOA GEFs activate RHOA - Danio rerio [Reaction:R-SSC-8980691] RHOA GEFs activate RHOA - Sus scrofa [Reaction:R-BTA-8980691] RHOA GEFs activate RHOA - Bos taurus [Reaction:R-CFA-8980691] RHOA GEFs activate RHOA - Canis familiaris [Reaction:R-RNO-8980691] RHOA GEFs activate RHOA - Rattus norvegicus [Reaction:R-MMU-8980691] RHOA GEFs activate RHOA - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-5665993] RHOA:GTP [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8980691
summation	[Summation:9644674] The following guanine nucleotide exchange factors (GEFs) wer...

Referrals

(precedingEvent)	[Reaction:R-HSA-8981637] RHOA GAPs stimulate RHOA GTPase activity [Reaction:R-HSA-9013009] RHOA binds effectors at the plasma membrane [BlackBoxEvent:R-HSA-9013006] RHOA:GTP translocates to the ER membrane
(hasEvent)	[Pathway:R-HSA-8980692] RHOA GTPase cycle
(replacementInstances)	[Deleted:9768327] Deletion of instance: 194913

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