Reactome | p115-RhoGEF activation of RHOA

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p115-RhoGEF activation of RHOA Show undefined attributes

catalystActivity	[CatalystActivity:139831] guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId	114544
displayName	p115-RhoGEF activation of RHOA
edited	[InstanceEdit:435388] Jupe, S, 2009-09-09 [InstanceEdit:9615256] Orlic-Milacic, Marija, 2018-07-31
eventOf	[Pathway:R-HSA-416482] G alpha (12/13) signalling events - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-8964174] RHOA:GDP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8874416] Activation of p115-RhoGEF requires direct association of G?13 and the Dbl homology domain
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p115-RhoGEF activation of RHOA
orthologousEvent	[Reaction:R-CEL-114544] p115-RhoGEF activation of RHOA - Caenorhabditis elegans [Reaction:R-DME-114544] p115-RhoGEF activation of RHOA - Drosophila melanogaster [Reaction:R-GGA-114544] p115-RhoGEF activation of RHOA - Gallus gallus [Reaction:R-SSC-114544] p115-RhoGEF activation of RHOA - Sus scrofa [Reaction:R-BTA-114544] p115-RhoGEF activation of RHOA - Bos taurus [Reaction:R-CFA-114544] p115-RhoGEF activation of RHOA - Canis familiaris [Reaction:R-RNO-114544] p115-RhoGEF activation of RHOA - Rattus norvegicus [Reaction:R-MMU-114544] p115-RhoGEF activation of RHOA - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-5665993] RHOA:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-114544
summation	[Summation:178379] ARHEF1 (p115-RhoGEF), recruited to the plasma membrane by bi...
updateTrackers	[UpdateTracker:9779160] Update Tracker - [Reaction:114544] p115-RhoGEF activation of RHOA - v66:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779160] Update Tracker - [Reaction:114544] p115-RhoGEF activation of RHOA - v66:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-416482] G alpha (12/13) signalling events