Reactome | RHOA:GTP binds ROCK, activating it

Schema > Reaction > Entries

RHOA:GTP binds ROCK, activating it Show undefined attributes

authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
dbId	3928576
displayName	RHOA:GTP binds ROCK, activating it
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
eventOf	[Pathway:R-HSA-3928662] EPHB-mediated forward signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-3928577] ROCK phosphorylates LIMK1,2 - Homo sapiens
input	[Complex:R-HSA-5665993] RHOA:GTP [plasma membrane] [DefinedSet:R-HSA-419057] ROCK1,ROCK2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3928042] Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RHOA:GTP binds ROCK, activating it
orthologousEvent	[Reaction:R-CEL-3928576] RHOA:GTP binds ROCK, activating it - Caenorhabditis elegans [Reaction:R-DME-3928576] RHOA:GTP binds ROCK, activating it - Drosophila melanogaster [Reaction:R-GGA-3928576] RHOA:GTP binds ROCK, activating it - Gallus gallus [Reaction:R-XTR-3928576] RHOA:GTP binds ROCK, activating it - Xenopus tropicalis [Reaction:R-DRE-3928576] RHOA:GTP binds ROCK, activating it - Danio rerio [Reaction:R-SSC-3928576] RHOA:GTP binds ROCK, activating it - Sus scrofa [Reaction:R-BTA-3928576] RHOA:GTP binds ROCK, activating it - Bos taurus [Reaction:R-CFA-3928576] RHOA:GTP binds ROCK, activating it - Canis familiaris [Reaction:R-RNO-3928576] RHOA:GTP binds ROCK, activating it - Rattus norvegicus [Reaction:R-MMU-3928576] RHOA:GTP binds ROCK, activating it - Mus musculus
output	[Complex:R-HSA-3928564] RHOA:GTP:ROCK1,ROCK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3928576
summation	[Summation:3928273] EPHB receptor-induced phosphorylation of coffin is at least ...
updateTrackers	[UpdateTracker:9780521] Update Tracker - [Reaction:3928576] RHOA:GTP binds ROCK, activating it - v62:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9780521] Update Tracker - [Reaction:3928576] RHOA:GTP binds ROCK, activating it - v62:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3928662] EPHB-mediated forward signaling
(precedingEvent)	[Reaction:R-HSA-3928577] ROCK phosphorylates LIMK1,2