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RHOA:GTP [plasma membrane]
Stable Identifier
R-HSA-5665993
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
Activated ROCK phosphorylates MRLCs (Homo sapiens)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
RHOA:GTP binds ROCK, activating it (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
ROCK phosphorylates LIMK1,2 (Homo sapiens)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
SLIT2:ROBO1 increases RHOA activity (Homo sapiens)
MYO9B inactivates RHOA (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR regulates axonogenesis (Homo sapiens)
Axonal growth inhibition (RHOA activation) (Homo sapiens)
RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
p115-RhoGEF activation of RHOA (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
ARHGAP35 binds RHOA:GTP (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
ERBB2 Regulates Cell Motility (Homo sapiens)
MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)
RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
ROCK1,ROCK2 are activated (Homo sapiens)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
DIAPH1 binds RHOA:GTP (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)
RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:DIAPH1:EVL:Profilin:G-actin [plasma membrane] (Homo sapiens)
RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHO GTPases Activate Rhotekin and Rhophilins (Homo sapiens)
RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:RHPN1,RHPN2 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:RTKN binds LIN7B (Homo sapiens)
RHOA:GTP:RTKN [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:RTKN:LIN7B [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)
RHOA:GTP:RTKN [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:RTKN:TAX1BP3 [plasma membrane] (Homo sapiens)
RHOA:GTP:RTKN [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
ROPN1 binds RHOA:GTP:RHPN1 (Homo sapiens)
RHOA:GTP:RHPN1 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:RHPN1:ROPN1 [plasma membrane] (Homo sapiens)
RHOA:GTP:RHPN1 [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT binds KIF14 and PRC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT:KIF14:PRC1 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
CIT-3 binds DLG4 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
RHOA:GTP translocates to the ER membrane (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)
Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
RHOA:GTP [plasma membrane] (Homo sapiens)
Participants
components
GTP [cytosol]
RHOA [plasma membrane]
(Homo sapiens)
Participates
as an input of
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA:GTP translocates to the ER membrane (Homo sapiens)
RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)
MYO9B inactivates RHOA (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
RHOA:GTP binds ROCK, activating it (Homo sapiens)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)
ARHGAP35 binds RHOA:GTP (Homo sapiens)
DIAPH1 binds RHOA:GTP (Homo sapiens)
as a component of
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA:GTP:RHPN1 [plasma membrane] (Homo sapiens)
RHOA:GTP:RHPN1,RHPN2 [plasma membrane] (Homo sapiens)
RHOA:GTP:RTKN:LIN7B [plasma membrane] (Homo sapiens)
RHOA:GTP:RTKN [plasma membrane] (Homo sapiens)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Homo sapiens)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Homo sapiens)
RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
as an output of
RHOA GEFs activate RHOA (Homo sapiens)
p115-RhoGEF activation of RHOA (Homo sapiens)
RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
as a member of
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Homo sapiens)
Inferred To
RhoA:GTP [plasma membrane]
(Mus musculus)
RHOA:GTP [plasma membrane]
(Bos taurus)
RHOA:GTP [plasma membrane]
(Caenorhabditis elegans)
RHOA:GTP [plasma membrane]
(Canis familiaris)
RHOA:GTP [plasma membrane]
(Danio rerio)
RHOA:GTP [plasma membrane]
(Drosophila melanogaster)
RHOA:GTP [plasma membrane]
(Gallus gallus)
RHOA:GTP [plasma membrane]
(Rattus norvegicus)
RHOA:GTP [plasma membrane]
(Saccharomyces cerevisiae)
RHOA:GTP [plasma membrane]
(Schizosaccharomyces pombe)
RHOA:GTP [plasma membrane]
(Sus scrofa)
RHOA:GTP [plasma membrane]
(Xenopus tropicalis)
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