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Schema
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Reaction
>
Entries
RhoA is activated by nucleotide exchange and inhibits axonal growth
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authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity
[CatalystActivity:9012796] guanyl-nucleotide exchange factor activity of MCF2 [cytosol]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:194547] Jassal, B, 2007-03-22 14:22:32
dbId
194518
displayName
RhoA is activated by nucleotide exchange and inhibits axonal growth
edited
[InstanceEdit:350668] Jassal, B, 2008-05-20 12:26:36
eventOf
[Pathway:R-HSA-193634] Axonal growth inhibition (RHOA activation) - Homo sapiens
input
[Complex:R-HSA-8964174] RHOA:GDP [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:194480] The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
RhoA is activated by nucleotide exchange and inhibits axonal growth
orthologousEvent
[Reaction:R-DRE-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Danio rerio
[Reaction:R-CEL-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Caenorhabditis elegans
[Reaction:R-DME-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Drosophila melanogaster
[Reaction:R-GGA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Gallus gallus
[Reaction:R-SSC-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Sus scrofa
[Reaction:R-BTA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Bos taurus
[Reaction:R-CFA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Canis familiaris
[Reaction:R-RNO-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Rattus norvegicus
[Reaction:R-MMU-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Mus musculus
output
[Complex:R-HSA-5665993] RHOA:GTP [plasma membrane]
precedingEvent
[Reaction:R-HSA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Homo sapiens
releaseDate
2008-06-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:350667] Friedman, WJ, 2008-05-20 12:23:46
[InstanceEdit:351795] Chao, MV, 2008-05-28 09:46:01
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-194518
summation
[Summation:194512] RHOA is activated by guanine nucleotide exchange factors (Rh...
updateTrackers
[UpdateTracker:9780707] Update Tracker - [Reaction:194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - v62:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9780707] Update Tracker - [Reaction:194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - v62:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
(hasEvent)
[Pathway:R-HSA-193634] Axonal growth inhibition (RHOA activation)
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