Reactome | RHOA:GTP:Mg2+ binds ROCK1,ROCK2

Schema > Reaction > Entries

RHOA:GTP:Mg2+ binds ROCK1,ROCK2 Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
dbId	3928647
displayName	RHOA:GTP:Mg2+ binds ROCK1,ROCK2
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-3928616] Activated ROCK phosphorylates MRLCs - Homo sapiens [Reaction:R-HSA-5228992] ROCK1,ROCK2 are activated - Homo sapiens
input	[Complex:R-HSA-5665993] RHOA:GTP [plasma membrane] [DefinedSet:R-HSA-419057] ROCK1,ROCK2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:421378] The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase [LiteratureReference:5229002] Crystal structure of a coiled-coil domain from human ROCK I
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RHOA:GTP:Mg2+ binds ROCK1,ROCK2
orthologousEvent	[Reaction:R-CEL-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Caenorhabditis elegans [Reaction:R-DME-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Drosophila melanogaster [Reaction:R-GGA-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Gallus gallus [Reaction:R-XTR-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Xenopus tropicalis [Reaction:R-DRE-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Danio rerio [Reaction:R-SSC-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Sus scrofa [Reaction:R-BTA-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Bos taurus [Reaction:R-CFA-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Canis familiaris [Reaction:R-RNO-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Rattus norvegicus [Reaction:R-MMU-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Mus musculus
output	[Complex:R-HSA-3928564] RHOA:GTP:ROCK1,ROCK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3928651] NGEF exchanges GTP for GDP on RHOA - Homo sapiens [Reaction:R-HSA-5218643] HSP90AA1 binds p-6Y-VEGFR2 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5218633] Positive regulation by 'VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane]'
regulationReference	[RegulationReference:9641764] Positive regulation by 'VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane]' Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3928647
summation	[Summation:3928307] RHOA propagates downstream signals by binding to effector pr... [Summation:5218536] Heat-shock protein of 90 kDa (HSP90) recruited to VEGFR2 ini...
updateTrackers	[UpdateTracker:9776041] Update Tracker - [Reaction:3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - v78:[addSummation] [UpdateTracker:9780723] Update Tracker - [Reaction:3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - v62:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9776041] Update Tracker - [Reaction:3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - v78:[addSummation] [UpdateTracker:9780723] Update Tracker - [Reaction:3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - v62:[add_removeInput]
(precedingEvent)	[Reaction:R-HSA-3928616] Activated ROCK phosphorylates MRLCs [Reaction:R-HSA-5228992] ROCK1,ROCK2 are activated
(hasEvent)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway

Cite Us!