Reactome | RHOA binds effectors at the plasma membrane

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RHOA binds effectors at the plasma membrane Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9013008] Orlic-Milacic, Marija, 2017-07-21
dbId	9013009
deleted	[Deleted:9716816] Deletion of instance: 194894
displayName	RHOA binds effectors at the plasma membrane
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-8980692] RHOA GTPase cycle - Homo sapiens
input	[CandidateSet:R-HSA-9013003] RHOA plasma membrane effectors [cytosol] [Complex:R-HSA-5665993] RHOA:GTP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:421378] The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase [LiteratureReference:5627666] The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton [LiteratureReference:5623615] Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB [LiteratureReference:5623625] Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1 [LiteratureReference:5623619] The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1 [LiteratureReference:5625892] A novel partner for the GTP-bound forms of rho and rac [LiteratureReference:5625916] Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron [LiteratureReference:9690094] The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics [LiteratureReference:5665985] Structural basis of Rho GTPase-mediated activation of the formin mDia1 [LiteratureReference:5665980] RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking [LiteratureReference:5665994] [PI3-kinase mediates activity of RhoA and interaction of RhoA with mDia1 in thrombin-induced platelet aggregation] [LiteratureReference:5666179] Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain [LiteratureReference:5666194] Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286 [LiteratureReference:5667003] Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho [LiteratureReference:5667009] The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:9690276] Anillin Promotes Cell Contractility by Cyclic Resetting of RhoA Residence Kinetics [LiteratureReference:9690284] Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis [LiteratureReference:9690318] Cytokinesis requires localized ?-actin filament production by an actin isoform specific nucleator [LiteratureReference:5666071] Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets [LiteratureReference:9694079] Specificity of interactions between mDia isoforms and Rho proteins [LiteratureReference:9690115] Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7 [LiteratureReference:9694064] Rho and anillin-dependent control of mDia2 localization and function in cytokinesis [LiteratureReference:9694068] Enhancement of mDia2 activity by Rho-kinase-dependent phosphorylation of the diaphanous autoregulatory domain [LiteratureReference:9694071] Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration [LiteratureReference:9694049] Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha [LiteratureReference:9694056] Interaction of the small G protein RhoA with the C terminus of human phospholipase D1 [LiteratureReference:449424] Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3 [LiteratureReference:419893] Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization [LiteratureReference:9691400] The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins [LiteratureReference:5665745] Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC [LiteratureReference:5626534] The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases [LiteratureReference:9694054] Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RHOA binds effectors at the plasma membrane
orthologousEvent	[Reaction:R-SCE-9013009] RHOA binds effectors at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SPO-9013009] RHOA binds effectors at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-MMU-9013009] RHOA binds effectors at the plasma membrane - Mus musculus [Reaction:R-RNO-9013009] RHOA binds effectors at the plasma membrane - Rattus norvegicus [Reaction:R-CFA-9013009] RHOA binds effectors at the plasma membrane - Canis familiaris [Reaction:R-BTA-9013009] RHOA binds effectors at the plasma membrane - Bos taurus [Reaction:R-SSC-9013009] RHOA binds effectors at the plasma membrane - Sus scrofa [Reaction:R-DRE-9013009] RHOA binds effectors at the plasma membrane - Danio rerio [Reaction:R-XTR-9013009] RHOA binds effectors at the plasma membrane - Xenopus tropicalis [Reaction:R-GGA-9013009] RHOA binds effectors at the plasma membrane - Gallus gallus [Reaction:R-DME-9013009] RHOA binds effectors at the plasma membrane - Drosophila melanogaster [Reaction:R-CEL-9013009] RHOA binds effectors at the plasma membrane - Caenorhabditis elegans
output	[Complex:R-HSA-9013010] RHOA:GTP:cytosolic RHOA effectors [plasma membrane]
precedingEvent	[Reaction:R-HSA-8980691] RHOA GEFs activate RHOA - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013009
summation	[Summation:9690101] In its GTP bound active form, plasma membrane associated RHO...

Referrals

(hasEvent)	[Pathway:R-HSA-8980692] RHOA GTPase cycle
(replacementInstances)	[Deleted:9716816] Deletion of instance: 194894

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