Reactome | DIAPH1 binds RHOA:GTP

Schema > Reaction > Entries

DIAPH1 binds RHOA:GTP Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5665990] Orlic-Milacic, Marija, 2015-01-20
dbId	5665989
displayName	DIAPH1 binds RHOA:GTP
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
followingEvent	[Reaction:R-HSA-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Homo sapiens [Reaction:R-HSA-6785648] MEMO1 binds RHOA:GTP:DIAPH1 - Homo sapiens
input	[Complex:R-HSA-5665967] DIAPH1 [cytosol] [Complex:R-HSA-5665993] RHOA:GTP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5665985] Structural basis of Rho GTPase-mediated activation of the formin mDia1 [LiteratureReference:5665980] RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking [LiteratureReference:5665994] [PI3-kinase mediates activity of RhoA and interaction of RhoA with mDia1 in thrombin-induced platelet aggregation]
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	DIAPH1 binds RHOA:GTP
orthologousEvent	[Reaction:R-CEL-5665989] DIAPH1 binds RHOA:GTP - Caenorhabditis elegans [Reaction:R-DME-5665989] DIAPH1 binds RHOA:GTP - Drosophila melanogaster [Reaction:R-SSC-5665989] DIAPH1 binds RHOA:GTP - Sus scrofa [Reaction:R-BTA-5665989] DIAPH1 binds RHOA:GTP - Bos taurus [Reaction:R-CFA-5665989] DIAPH1 binds RHOA:GTP - Canis familiaris [Reaction:R-RNO-5665989] DIAPH1 binds RHOA:GTP - Rattus norvegicus [Reaction:R-MMU-5665989] DIAPH1 binds RHOA:GTP - Mus musculus
output	[Complex:R-HSA-5665988] RHOA:GTP:DIAPH1 [plasma membrane]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5665989
summation	[Summation:5665991] DIAPH1 is activated by binding of the DIAPH1 dimer to GTP-bo...

Referrals

(hasEvent)	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-HSA-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 [Reaction:R-HSA-6785648] MEMO1 binds RHOA:GTP:DIAPH1