Reactome | RHO GTPases Activate Formins

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RHO GTPases Activate Formins Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:5663221] Orlic-Milacic, Marija, 2015-01-16
dbId	5663220
displayName	RHO GTPases Activate Formins
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-195258] RHO GTPase Effectors - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5663232] FMNL1 binds RAC1:GTP - Homo sapiens [Reaction:R-HSA-203070] Association of profilin with monomeric actin - Homo sapiens [Reaction:R-HSA-5665659] RAC1:GTP:FMNL1 binds profilin:G-actin - Homo sapiens [Reaction:R-HSA-5665802] SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin - Homo sapiens [Reaction:R-HSA-5665809] SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments - Homo sapiens [Reaction:R-HSA-5665686] FMNL1 binds CDC42:GTP - Homo sapiens [Reaction:R-HSA-5665727] FMNL2 binds CDC42:GTP - Homo sapiens [Reaction:R-HSA-5665751] CDC42:GTP:FMNL2 binds Profilin:G-actin - Homo sapiens [Reaction:R-HSA-5665748] FMNL2 binds RHOC:GTP - Homo sapiens [Reaction:R-HSA-5665761] FMNL3 binds RHOC:GTP - Homo sapiens [Reaction:R-HSA-5665767] Activated FMNL3 binds G-actin - Homo sapiens [Reaction:R-HSA-5666001] Profilin:G-actin binds MKL1 - Homo sapiens [Reaction:R-HSA-5665989] DIAPH1 binds RHOA:GTP - Homo sapiens [Reaction:R-HSA-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Homo sapiens [Reaction:R-HSA-5665999] MKL1 translocates from cytosol to the nucleus - Homo sapiens [Reaction:R-HSA-5665998] MKL1 binds SRF - Homo sapiens [Reaction:R-HSA-5666008] SCAI binds SRF:MKL1 - Homo sapiens [Reaction:R-HSA-5666046] SRF:MKL1 binds ITGB1 Gene - Homo sapiens [BlackBoxEvent:R-HSA-5666049] SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it - Homo sapiens [Reaction:R-HSA-5666070] RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes - Homo sapiens [Reaction:R-HSA-5666088] RHOD:GTP recruits DAIPH2-3 to endosomes - Homo sapiens [Reaction:R-HSA-5666104] RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes - Homo sapiens [Reaction:R-HSA-5666129] CDC42:GTP recruits DIAPH2-2 to kinetochores - Homo sapiens [Reaction:R-HSA-5666160] AURKB phosphorylates DIAPH2-2 at kinetochores - Homo sapiens [Reaction:R-HSA-5666169] Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 - Homo sapiens [Reaction:R-HSA-3858495] DAAM1 recruits GTP-bound RHOA - Homo sapiens [Reaction:R-HSA-3858489] ppDVL binds DAAM1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5665955] Formins as effector proteins of Rho GTPases [LiteratureReference:5672364] The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition [LiteratureReference:5663236] The regulation of mDia1 by autoinhibition and its release by Rho*GTP [LiteratureReference:5672362] Structure of the autoinhibitory switch in formin mDia1 [LiteratureReference:5665948] Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture [LiteratureReference:5665961] Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis [LiteratureReference:5665957] Control of the assembly of ATP- and ADP-actin by formins and profilin [LiteratureReference:5663237] FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages [LiteratureReference:5665704] Dynamic remodeling of the actin cytoskeleton by FMNL1? is required for structural maintenance of the Golgi complex [LiteratureReference:5665683] Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1 [LiteratureReference:5665745] Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC [LiteratureReference:5665763] RhoA and RhoC have distinct roles in migration and invasion by acting through different targets [LiteratureReference:5665974] Actin dynamics control SRF activity by regulation of its coactivator MAL [LiteratureReference:5666075] RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1 [LiteratureReference:5666061] RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking [LiteratureReference:5666101] Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling [LiteratureReference:5666086] RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase [LiteratureReference:5666124] Cdc42 and mDia3 regulate microtubule attachment to kinetochores [LiteratureReference:5666138] Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment [LiteratureReference:351112] Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 [LiteratureReference:5666152] A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility [LiteratureReference:5672935] The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RHO GTPases Activate Formins
orthologousEvent	[Pathway:R-RNO-5663220] RHO GTPases Activate Formins - Rattus norvegicus [Pathway:R-DME-5663220] RHO GTPases Activate Formins - Drosophila melanogaster [Pathway:R-CEL-5663220] RHO GTPases Activate Formins - Caenorhabditis elegans [Pathway:R-XTR-5663220] RHO GTPases Activate Formins - Xenopus tropicalis [Pathway:R-GGA-5663220] RHO GTPases Activate Formins - Gallus gallus [Pathway:R-DRE-5663220] RHO GTPases Activate Formins - Danio rerio [Pathway:R-SSC-5663220] RHO GTPases Activate Formins - Sus scrofa [Pathway:R-BTA-5663220] RHO GTPases Activate Formins - Bos taurus [Pathway:R-CFA-5663220] RHO GTPases Activate Formins - Canis familiaris [Pathway:R-MMU-5663220] RHO GTPases Activate Formins - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5663220
summation	[Summation:5672351] Formins are a family of proteins with 15 members in mammals,...

Referrals

(hasEvent)	[Pathway:R-HSA-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-HSA-1227986] Signaling by ERBB2 [Pathway:R-HSA-8848021] Signaling by PTK6

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