Reactome | RHO GTPase Effectors

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RHO GTPase Effectors Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
created	[InstanceEdit:195257] Gopinathrao, G, 2007-04-03 11:42:01
dbId	195258
displayName	RHO GTPase Effectors
doi	10.3180/REACT_355444.1
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-194315] Signaling by Rho GTPases - Homo sapiens
figure	[Figure:9628935] /figures/ehld/R-HSA-195258.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-5627117] RHO GTPases Activate ROCKs - Homo sapiens [Pathway:R-HSA-5627123] RHO GTPases activate PAKs - Homo sapiens [Pathway:R-HSA-5625740] RHO GTPases activate PKNs - Homo sapiens [Pathway:R-HSA-5625900] RHO GTPases activate CIT - Homo sapiens [Pathway:R-HSA-5625970] RHO GTPases activate KTN1 - Homo sapiens [Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs - Homo sapiens [Pathway:R-HSA-5627083] RHO GTPases regulate CFTR trafficking - Homo sapiens [Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs - Homo sapiens [Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens [Pathway:R-HSA-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Homo sapiens [Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:5663095] RHO-GTPases and cancer [LiteratureReference:419192] Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) [LiteratureReference:421378] The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase [LiteratureReference:5627666] The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton [LiteratureReference:420679] Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop [LiteratureReference:420676] Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase [LiteratureReference:419067] Rocks: multifunctional kinases in cell behaviour [LiteratureReference:419187] Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells [LiteratureReference:442649] A brain serine/threonine protein kinase activated by Cdc42 and Rac1 [LiteratureReference:5628821] Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family [LiteratureReference:5628823] Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA [LiteratureReference:399902] Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics [LiteratureReference:5627780] Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch [LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 [LiteratureReference:389773] p21-activated protein kinase: a crucial component of morphological signaling? [LiteratureReference:434953] Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements [LiteratureReference:5623619] The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1 [LiteratureReference:5624305] Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation [LiteratureReference:5624312] Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1) [LiteratureReference:5624309] The Rac1 polybasic region is required for interaction with its effector PRK1 [LiteratureReference:5623625] Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1 [LiteratureReference:5623615] Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB [LiteratureReference:5623634] Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase [LiteratureReference:5623676] Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1 [LiteratureReference:5625719] A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer [LiteratureReference:4687010] LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription [LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation [LiteratureReference:5625892] A novel partner for the GTP-bound forms of rho and rac [LiteratureReference:5625942] Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation [LiteratureReference:5625921] KIF14 and citron kinase act together to promote efficient cytokinesis [LiteratureReference:5625914] Citron kinase controls a molecular network required for midbody formation in cytokinesis [LiteratureReference:5625944] Citron kinase mediates transition from constriction to abscission through its coiled-coil domain [LiteratureReference:5625953] Kinectin is a key effector of RhoG microtubule-dependent cellular activity [LiteratureReference:5625958] Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor [LiteratureReference:5626508] Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1 [LiteratureReference:5626520] IQGAP1 is a component of Cdc42 signaling to the cytoskeleton [LiteratureReference:5626488] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth [LiteratureReference:5626534] The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases [LiteratureReference:5626533] Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42 [LiteratureReference:5626541] IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments [LiteratureReference:5626515] The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration [LiteratureReference:5627085] PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 [LiteratureReference:5627065] Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10 [LiteratureReference:5672374] Structure and role of WASP and WAVE in Rho GTPase signalling in cancer [LiteratureReference:5665955] Formins as effector proteins of Rho GTPases [LiteratureReference:5665974] Actin dynamics control SRF activity by regulation of its coactivator MAL [LiteratureReference:5666206] Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons [LiteratureReference:5666211] The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element [LiteratureReference:5667003] Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho [LiteratureReference:5667009] The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization [LiteratureReference:5667062] Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella [LiteratureReference:5667027] Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP [LiteratureReference:5668623] Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 [LiteratureReference:5668665] Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense [LiteratureReference:5668616] Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways [LiteratureReference:5668679] Interaction of inducible nitric oxide synthase with rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes: implication in microbial killing [LiteratureReference:5668717] Nox1-dependent reactive oxygen generation is regulated by Rac1 [LiteratureReference:5668702] Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1 [LiteratureReference:5668733] Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases [LiteratureReference:5671798] Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N [LiteratureReference:5672907] Proteolytic activation of PKN by caspase-3 or related protease during apoptosis [LiteratureReference:5672307] Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells [LiteratureReference:5672327] Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 [LiteratureReference:5672306] Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion [LiteratureReference:5672323] Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	RHO GTPase Effectors
orthologousEvent	[Pathway:R-PFA-195258] RHO GTPase Effectors - Plasmodium falciparum [Pathway:R-SCE-195258] RHO GTPase Effectors - Saccharomyces cerevisiae [Pathway:R-SPO-195258] RHO GTPase Effectors - Schizosaccharomyces pombe [Pathway:R-DDI-195258] RHO GTPase Effectors - Dictyostelium discoideum [Pathway:R-CEL-195258] RHO GTPase Effectors - Caenorhabditis elegans [Pathway:R-DME-195258] RHO GTPase Effectors - Drosophila melanogaster [Pathway:R-GGA-195258] RHO GTPase Effectors - Gallus gallus [Pathway:R-XTR-195258] RHO GTPase Effectors - Xenopus tropicalis [Pathway:R-DRE-195258] RHO GTPase Effectors - Danio rerio [Pathway:R-SSC-195258] RHO GTPase Effectors - Sus scrofa [Pathway:R-BTA-195258] RHO GTPase Effectors - Bos taurus [Pathway:R-CFA-195258] RHO GTPase Effectors - Canis familiaris [Pathway:R-RNO-195258] RHO GTPase Effectors - Rattus norvegicus [Pathway:R-MMU-195258] RHO GTPase Effectors - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-195258
summation	[Summation:196653] RHO GTPases regulate cell behaviour by activating a number o...
updateTrackers	[UpdateTracker:9780287] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v63:[updateContainedPathway] [UpdateTracker:9776711] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9864077] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v88:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781751] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v60:[updateIndirectRLE] [UpdateTracker:9781284] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v61:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778701] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v67:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9779812] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v64:[updateIndirectRLE] [UpdateTracker:9782468] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v59:[updateIndirectRLE] [UpdateTracker:9783901] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v55:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783201] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v57:[updateIndirectRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-194315] Signaling by Rho GTPases

(updatedInstance)

[UpdateTracker:9780287] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v63:[updateContainedPathway]
[UpdateTracker:9776711] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v74:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9864077] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v88:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781751] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v60:[updateIndirectRLE]
[UpdateTracker:9781284] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v61:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778701] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v67:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9779812] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v64:[updateIndirectRLE]
[UpdateTracker:9782468] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v59:[updateIndirectRLE]
[UpdateTracker:9783901] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v55:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9783201] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v57:[updateIndirectRLE]

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