Reactome | Activated FMNL3 binds G-actin

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Activated FMNL3 binds G-actin Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5665766] Orlic-Milacic, Marija, 2015-01-19
dbId	5665767
displayName	Activated FMNL3 binds G-actin
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
input	2 × [Complex:R-HSA-203080] Profilin:G-actin [cytosol] [Complex:R-HSA-5665759] RHOC:GTP:FMNL3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5665771] FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation [LiteratureReference:5665763] RhoA and RhoC have distinct roles in migration and invasion by acting through different targets [LiteratureReference:5665778] The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends [LiteratureReference:5665790] The formin FMNL3 is a cytoskeletal regulator of angiogenesis [LiteratureReference:5665961] Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis [LiteratureReference:5665957] Control of the assembly of ATP- and ADP-actin by formins and profilin [LiteratureReference:5665955] Formins as effector proteins of Rho GTPases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated FMNL3 binds G-actin
orthologousEvent	[Reaction:R-GGA-5665767] Activated FMNL3 binds G-actin - Gallus gallus [Reaction:R-XTR-5665767] Activated FMNL3 binds G-actin - Xenopus tropicalis [Reaction:R-DRE-5665767] Activated FMNL3 binds G-actin - Danio rerio [Reaction:R-SSC-5665767] Activated FMNL3 binds G-actin - Sus scrofa [Reaction:R-BTA-5665767] Activated FMNL3 binds G-actin - Bos taurus [Reaction:R-CFA-5665767] Activated FMNL3 binds G-actin - Canis familiaris [Reaction:R-RNO-5665767] Activated FMNL3 binds G-actin - Rattus norvegicus [Reaction:R-MMU-5665767] Activated FMNL3 binds G-actin - Mus musculus
output	[Complex:R-HSA-5665773] RHOC:GTP:FMNL3:G-actin [plasma membrane]
precedingEvent	[Reaction:R-HSA-5665761] FMNL3 binds RHOC:GTP - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5665767
summation	[Summation:5665776] Activated FMNL3 (presumably associated with RHOC:GTP) has th...

Referrals

(hasEvent)

[Pathway:R-HSA-5663220] RHO GTPases Activate Formins

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