Reactome | RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1

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RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5665990] Orlic-Milacic, Marija, 2015-01-20
dbId	5665982
displayName	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
followingEvent	[Reaction:R-HSA-5665999] MKL1 translocates from cytosol to the nucleus - Homo sapiens
input	[Complex:R-HSA-5665986] EVL [cytosol] 2 × [Complex:R-HSA-5665995] Profilin:G-actin:MKL1 [cytosol] [Complex:R-HSA-5665988] RHOA:GTP:DIAPH1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5665974] Actin dynamics control SRF activity by regulation of its coactivator MAL [LiteratureReference:5666032] The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization [LiteratureReference:5666024] A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity [LiteratureReference:5666026] Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation [LiteratureReference:5666028] High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
orthologousEvent	[Reaction:R-SSC-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Sus scrofa [Reaction:R-CFA-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Canis familiaris [Reaction:R-RNO-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Rattus norvegicus [Reaction:R-MMU-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Mus musculus
output	2 × [EntityWithAccessionedSequence:R-HSA-5665975] MKL1 [cytosol] [Complex:R-HSA-5665977] RHOA:GTP:DIAPH1:EVL:Profilin:G-actin [plasma membrane]
precedingEvent	[Reaction:R-HSA-5665989] DIAPH1 binds RHOA:GTP - Homo sapiens [Reaction:R-HSA-5666001] Profilin:G-actin binds MKL1 - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5665982
summation	[Summation:5666041] Once activated by binding to RHOA:GTP, DIAPH1 binds profilin...

Referrals

(hasEvent)	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-HSA-5665999] MKL1 translocates from cytosol to the nucleus