Reactome | SRF:MKL1 binds ITGB1 Gene

Schema > Reaction > Entries

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5666048] Orlic-Milacic, Marija, 2015-01-20
dbId	5666046
displayName	SRF:MKL1 binds ITGB1 Gene
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5666049] SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5666054] ITGB1 gene [nucleoplasm] [Complex:R-HSA-5666002] SRF:MKL1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5666004] SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRF:MKL1 binds ITGB1 Gene
output	[Complex:R-HSA-5666050] SRF:MKL1:ITGB1 Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5665998] MKL1 binds SRF - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5666046
summation	[Summation:5666051] SRF:MKL1 transcription complex binds the promoter region of ...

(hasEvent)	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[BlackBoxEvent:R-HSA-5666049] SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it

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