Reactome | RHO GTPases Activate Formins

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RHO GTPases Activate Formins Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099821
displayName	RHO GTPases Activate Formins
eventOf	[Pathway:R-MMU-195258] RHO GTPase Effectors - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-203070] Association of profilin with monomeric actin - Mus musculus [Reaction:R-MMU-5665802] SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin - Mus musculus [Reaction:R-MMU-5665809] SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments - Mus musculus [Reaction:R-MMU-5665727] FMNL2 binds CDC42:GTP - Mus musculus [Reaction:R-MMU-5665751] CDC42:GTP:FMNL2 binds Profilin:G-actin - Mus musculus [Reaction:R-MMU-5665748] FMNL2 binds RHOC:GTP - Mus musculus [Reaction:R-MMU-5665761] FMNL3 binds RHOC:GTP - Mus musculus [Reaction:R-MMU-5665767] Activated FMNL3 binds G-actin - Mus musculus [Reaction:R-MMU-5666001] Profilin:G-actin binds MKL1 - Mus musculus [Reaction:R-MMU-5665989] DIAPH1 binds RHOA:GTP - Mus musculus [Reaction:R-MMU-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Mus musculus [Reaction:R-MMU-5665999] MKL1 translocates from cytosol to the nucleus - Mus musculus [Reaction:R-MMU-5665998] MKL1 binds SRF - Mus musculus [Reaction:R-MMU-5666008] SCAI binds SRF:MKL1 - Mus musculus [Reaction:R-MMU-5666070] RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes - Mus musculus [Reaction:R-MMU-5666129] CDC42:GTP recruits DIAPH2-2 to kinetochores - Mus musculus [Reaction:R-MMU-5666160] AURKB phosphorylates DIAPH2-2 at kinetochores - Mus musculus [Reaction:R-MMU-5666169] Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 - Mus musculus [Reaction:R-MMU-3858495] DAAM1 recruits GTP-bound RHOA - Mus musculus [Reaction:R-MMU-3858489] ppDVL binds DAAM1 - Mus musculus
inferredFrom	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases Activate Formins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5663220
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-MMU-8848021] Signaling by PTK6 [Pathway:R-MMU-1227986] Signaling by ERBB2
(inferredTo)	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins

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