Reactome | RAC1:GTP:FMNL1 binds profilin:G-actin

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RAC1:GTP:FMNL1 binds profilin:G-actin Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5665655] Orlic-Milacic, Marija, 2015-01-19
dbId	5665659
displayName	RAC1:GTP:FMNL1 binds profilin:G-actin
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
followingEvent	[Reaction:R-HSA-5665802] SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin - Homo sapiens
inferredFrom	[Reaction:R-MMU-5665656] Rac1:GTP:Fmnl1 binds Pfn1,Pfn2 - Mus musculus
input	2 × [Complex:R-HSA-203080] Profilin:G-actin [cytosol] [Complex:R-HSA-5663231] RAC1:GTP:FMNL1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5663237] FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages [LiteratureReference:5665704] Dynamic remodeling of the actin cytoskeleton by FMNL1? is required for structural maintenance of the Golgi complex [LiteratureReference:5665957] Control of the assembly of ATP- and ADP-actin by formins and profilin [LiteratureReference:5665961] Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis [LiteratureReference:5665955] Formins as effector proteins of Rho GTPases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAC1:GTP:FMNL1 binds profilin:G-actin
output	[Complex:R-HSA-5665660] RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane]
precedingEvent	[Reaction:R-HSA-5663232] FMNL1 binds RAC1:GTP - Homo sapiens [Reaction:R-HSA-203070] Association of profilin with monomeric actin - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5665659
summation	[Summation:5665658] FMNL1, activated by binding to GTP-bound RAC1, binds actin-a...

Referrals

(hasEvent)	[Pathway:R-HSA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-HSA-5665802] SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
(inferredTo)	[Reaction:R-MMU-5665656] Rac1:GTP:Fmnl1 binds Pfn1,Pfn2

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