Reactome | RHO GTPases Activate WASPs and WAVEs

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RHO GTPases Activate WASPs and WAVEs Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
created	[InstanceEdit:5663212] Orlic-Milacic, Marija, 2015-01-16
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	5663213
displayName	RHO GTPases Activate WASPs and WAVEs
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-195258] RHO GTPase Effectors - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 - Homo sapiens [Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them - Homo sapiens [Reaction:R-HSA-2197698] Src phosphorylate WASP,N-WASP - Homo sapiens [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens [Reaction:R-HSA-2130194] ABL phosphorylates WAVEs - Homo sapiens [Reaction:R-HSA-2029469] p-ERK phosphorylates WAVEs and ABI - Homo sapiens [Reaction:R-HSA-442592] WASPs or WAVEs activate the ARP2/3 complex - Homo sapiens [Reaction:R-HSA-2029466] (WASPs, WAVE):G-actin:ARP2/3 binds F-actin - Homo sapiens [Reaction:R-HSA-2197690] Detachment of WASP/WAVE - Homo sapiens [BlackBoxEvent:R-HSA-2029473] Branching and elongation of mother and daughter filaments - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[LiteratureReference:5672374] Structure and role of WASP and WAVE in Rho GTPase signalling in cancer
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	RHO GTPases Activate WASPs and WAVEs
orthologousEvent	[Pathway:R-MMU-5663213] RHO GTPases Activate WASPs and WAVEs - Mus musculus [Pathway:R-SCE-5663213] RHO GTPases Activate WASPs and WAVEs - Saccharomyces cerevisiae [Pathway:R-SPO-5663213] RHO GTPases Activate WASPs and WAVEs - Schizosaccharomyces pombe [Pathway:R-DDI-5663213] RHO GTPases Activate WASPs and WAVEs - Dictyostelium discoideum [Pathway:R-CEL-5663213] RHO GTPases Activate WASPs and WAVEs - Caenorhabditis elegans [Pathway:R-DME-5663213] RHO GTPases Activate WASPs and WAVEs - Drosophila melanogaster [Pathway:R-GGA-5663213] RHO GTPases Activate WASPs and WAVEs - Gallus gallus [Pathway:R-XTR-5663213] RHO GTPases Activate WASPs and WAVEs - Xenopus tropicalis [Pathway:R-DRE-5663213] RHO GTPases Activate WASPs and WAVEs - Danio rerio [Pathway:R-SSC-5663213] RHO GTPases Activate WASPs and WAVEs - Sus scrofa [Pathway:R-BTA-5663213] RHO GTPases Activate WASPs and WAVEs - Bos taurus [Pathway:R-CFA-5663213] RHO GTPases Activate WASPs and WAVEs - Canis familiaris [Pathway:R-RNO-5663213] RHO GTPases Activate WASPs and WAVEs - Rattus norvegicus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5663213
summation	[Summation:5672377] WASP and WAVE proteins belong to the Wiskott-Aldrich Syndrom...
updateTrackers	[UpdateTracker:9781861] Update Tracker - [Pathway:5663213] RHO GTPases Activate WASPs and WAVEs - v60:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9781861] Update Tracker - [Pathway:5663213] RHO GTPases Activate WASPs and WAVEs - v60:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-HSA-8848021] Signaling by PTK6 [Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)

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