Reactome | RHO GTPases Activate WASPs and WAVEs

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RHO GTPases Activate WASPs and WAVEs Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649630
displayName	RHO GTPases Activate WASPs and WAVEs
eventOf	[Pathway:R-DRE-195258] RHO GTPase Effectors - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-2197691] WIP binds WASP,N-WASP, activating them - Danio rerio [Reaction:R-DRE-2130194] ABL phosphorylates WAVEs - Danio rerio [Reaction:R-DRE-2029469] p-ERK phosphorylates WAVEs and ABI - Danio rerio [Reaction:R-DRE-2029466] (WASPs, WAVE):G-actin:ARP2/3 binds F-actin - Danio rerio [Reaction:R-DRE-2197690] Detachment of WASP/WAVE - Danio rerio [BlackBoxEvent:R-DRE-2029473] Branching and elongation of mother and daughter filaments - Danio rerio
inferredFrom	[Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases Activate WASPs and WAVEs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-5663213
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-DRE-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-5663213] RHO GTPases Activate WASPs and WAVEs

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