Reactome | Ion homeostasis

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Ion homeostasis Show undefined attributes

authored	[InstanceEdit:5578800] Jassal, Bijay, 2014-06-02
created	[InstanceEdit:5578800] Jassal, Bijay, 2014-06-02
crossReference	[DatabaseIdentifier:12819579] BioModels Database:BIOMD0000000464
dbId	5578775
displayName	Ion homeostasis
edited	[InstanceEdit:5578800] Jassal, Bijay, 2014-06-02
eventOf	[Pathway:R-HSA-5576891] Cardiac conduction - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5673483] regulation of cardiac conduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-425661] SLC8A1,2,3 exchange 3Na+ for Ca2+ - Homo sapiens [Reaction:R-HSA-5578777] DMPK phosphorylates PLN - Homo sapiens [Reaction:R-HSA-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Homo sapiens [Reaction:R-HSA-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Homo sapiens [Reaction:R-HSA-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Homo sapiens [Reaction:R-HSA-434798] CRAC translocates calcium from the extracellular region to the cytosol - Homo sapiens [Reaction:R-HSA-2855020] RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol - Homo sapiens [Reaction:R-HSA-169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - Homo sapiens [Reaction:R-HSA-5226904] AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it - Homo sapiens [Reaction:R-HSA-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Homo sapiens [Reaction:R-HSA-139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol - Homo sapiens [Reaction:R-HSA-418309] ATP2B1-4 transport cytosolic Ca2+ to extracellular region - Homo sapiens [Reaction:R-HSA-5617178] ATP2B4 binds to NOS1, inhibiting it - Homo sapiens [Reaction:R-HSA-5617182] PRKACA phosphorylates PLN - Homo sapiens [Reaction:R-HSA-5617179] PRKACA phosphorylates TNNI3 - Homo sapiens [Reaction:R-HSA-5678261] KCNJ11:ABCC9 transports K+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-9691566] KCNJ11:ABCC9 binds nicorandil - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:6797407] Physiological and pharmacological insights into the role of ionic channels in cardiac pacemaker activity [LiteratureReference:6797408] Ion Channels in the Heart
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Ion homeostasis
orthologousEvent	[Pathway:R-PFA-5578775] Ion homeostasis - Plasmodium falciparum [Pathway:R-SCE-5578775] Ion homeostasis - Saccharomyces cerevisiae [Pathway:R-SPO-5578775] Ion homeostasis - Schizosaccharomyces pombe [Pathway:R-DDI-5578775] Ion homeostasis - Dictyostelium discoideum [Pathway:R-CEL-5578775] Ion homeostasis - Caenorhabditis elegans [Pathway:R-DME-5578775] Ion homeostasis - Drosophila melanogaster [Pathway:R-GGA-5578775] Ion homeostasis - Gallus gallus [Pathway:R-XTR-5578775] Ion homeostasis - Xenopus tropicalis [Pathway:R-DRE-5578775] Ion homeostasis - Danio rerio [Pathway:R-SSC-5578775] Ion homeostasis - Sus scrofa [Pathway:R-BTA-5578775] Ion homeostasis - Bos taurus [Pathway:R-CFA-5578775] Ion homeostasis - Canis familiaris [Pathway:R-RNO-5578775] Ion homeostasis - Rattus norvegicus [Pathway:R-MMU-5578775] Ion homeostasis - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6809173] Colotti, Gianni, 2015-11-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5578775
summation	[Summation:6797404] Ion channels and ion homeostasis in relation to cardiac cond...
updateTrackers	[UpdateTracker:9774790] Update Tracker - [Pathway:5578775] Ion homeostasis - v81:[addHasEvent] [UpdateTracker:9780699] Update Tracker - [Pathway:5578775] Ion homeostasis - v62:[updateContainedRLE] [UpdateTracker:9776807] Update Tracker - [Pathway:5578775] Ion homeostasis - v74:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9782042] Update Tracker - [Pathway:5578775] Ion homeostasis - v59:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9774790] Update Tracker - [Pathway:5578775] Ion homeostasis - v81:[addHasEvent]
[UpdateTracker:9780699] Update Tracker - [Pathway:5578775] Ion homeostasis - v62:[updateContainedRLE]
[UpdateTracker:9776807] Update Tracker - [Pathway:5578775] Ion homeostasis - v74:[addHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9782042] Update Tracker - [Pathway:5578775] Ion homeostasis - v59:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-5576891] Cardiac conduction

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