Reactome | Ion homeostasis

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Ion homeostasis Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649046
displayName	Ion homeostasis
eventOf	[Pathway:R-DRE-5576891] Cardiac conduction - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5673483] regulation of cardiac conduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-425661] SLC8A1,2,3 exchange 3Na+ for Ca2+ - Danio rerio [Reaction:R-DRE-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Danio rerio [Reaction:R-DRE-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Danio rerio [Reaction:R-DRE-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Danio rerio [Reaction:R-DRE-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Danio rerio [Reaction:R-DRE-418309] ATP2B1-4 transport cytosolic Ca2+ to extracellular region - Danio rerio [Reaction:R-DRE-5617179] PRKACA phosphorylates TNNI3 - Danio rerio
inferredFrom	[Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Ion homeostasis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-5578775
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5576891] Cardiac conduction
(inferredTo)	[Pathway:R-HSA-5578775] Ion homeostasis

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