Reactome | TRPC1 translocates calcium from the extracellular region to the cytosol

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TRPC1 translocates calcium from the extracellular region to the cytosol Show undefined attributes

authored	[InstanceEdit:2084238] May, B, 2012-01-31
catalystActivity	[CatalystActivity:2089928] monoatomic cation channel activity of STIM1:TRPC1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643866] cation channel activity of STIM1:TRPC1 [plasma membrane] STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2089924] May, B, 2012-02-05
crossReference	[DatabaseIdentifier:12667421] RHEA:29671
dbId	2089943
displayName	TRPC1 translocates calcium from the extracellular region to the cytosol
edited	[InstanceEdit:2084238] May, B, 2012-01-31
eventOf	[Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens [Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent	[Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2089952] STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction [LiteratureReference:2089921] STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels [LiteratureReference:2089914] The Ca2+ Sensor STIM1 is Necessary and Sufficient for the Store-Operated Ca2+ Entry Function of TRPCs in Endothelial Cells [LiteratureReference:2089917] Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	TRPC1 translocates calcium from the extracellular region to the cytosol Calcium Influx via TRPC1
orthologousEvent	[Reaction:R-CEL-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Caenorhabditis elegans [Reaction:R-DME-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Drosophila melanogaster [Reaction:R-GGA-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Gallus gallus [Reaction:R-XTR-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Xenopus tropicalis [Reaction:R-DRE-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Danio rerio [Reaction:R-SSC-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Sus scrofa [Reaction:R-BTA-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Bos taurus [Reaction:R-CFA-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Canis familiaris [Reaction:R-RNO-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Rattus norvegicus [Reaction:R-MMU-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Mus musculus
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
precedingEvent	[Reaction:R-HSA-2089927] STIM1 binds TRPC1 forming STIM1:TRPC1 complex - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2089943
summation	[Summation:2089956] TRPC1 forms a channel that transports Ca2+ across the plasma...

Referrals

(hasEvent)	[Pathway:R-HSA-5578775] Ion homeostasis [Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[Reaction:R-HSA-74448] Calcium binds calmodulin