Reactome | ATP1A:ATP1B:FXYD binds cardiac glycosides

Schema > Reaction > Entries

ATP1A:ATP1B:FXYD binds cardiac glycosides Show undefined attributes

authored	[InstanceEdit:9684071] Jassal, Bijay, 2020-04-20
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9684071] Jassal, Bijay, 2020-04-20
dbId	9684068
definition	Inhibition
displayName	ATP1A:ATP1B:FXYD binds cardiac glycosides
edited	[InstanceEdit:9684071] Jassal, Bijay, 2020-04-20
eventOf	[Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens [Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens [Pathway:R-HSA-936837] Ion transport by P-type ATPases - Homo sapiens
input	[Complex:R-HSA-936770] ATP1A:ATP1B:FXYD [plasma membrane] [DefinedSet:R-ALL-9684063] cardiac glycosides [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9684058] The basic mechanism of inotropic action of digitalis glycosides [LiteratureReference:9690292] Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1 [LiteratureReference:9684075] Inhibition of Non Canonical HIV-1 Tat Secretion Through the Cellular Na⁺,K⁺-ATPase Blocks HIV-1 Infection [LiteratureReference:9690291] Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase [LiteratureReference:9690305] Cardiac glycosides induced toxicity in human cells expressing ?1-, ?2-, or ?3-isoforms of Na-K-ATPase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ATP1A:ATP1B:FXYD binds cardiac glycosides
orthologousEvent	[Reaction:R-GGA-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Gallus gallus [Reaction:R-XTR-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Xenopus tropicalis [Reaction:R-DRE-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Danio rerio [Reaction:R-SSC-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Sus scrofa [Reaction:R-BTA-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Bos taurus [Reaction:R-CFA-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Canis familiaris [Reaction:R-RNO-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Rattus norvegicus [Reaction:R-MMU-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Mus musculus
output	[Complex:R-HSA-9684072] ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9684068
summation	[Summation:9684059] Cardiac glycosides are a class of organic compounds that inc...
updateTrackers	[UpdateTracker:9776654] Update Tracker - [Reaction:9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - v74:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776654] Update Tracker - [Reaction:9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - v74:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-5578775] Ion homeostasis [Pathway:R-HSA-9679191] Potential therapeutics for SARS [Pathway:R-HSA-936837] Ion transport by P-type ATPases

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