Reactome | ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+

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ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ Show undefined attributes

authored	[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
catalystActivity	[CatalystActivity:936847] P-type sodium:potassium-exchanging transporter activity of ATP1A:ATP1B:FXYD [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
dbId	936897
displayName	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
edited	[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
eventOf	[Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens [Pathway:R-HSA-936837] Ion transport by P-type ATPases - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-74126] K+ [extracellular region] 3 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:936834] Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence [LiteratureReference:936790] Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms [LiteratureReference:936778] Family of human Na+, K+-ATPase genes. Structure of the gene for the catalytic subunit (alpha III-form) and its relationship with structural features of the protein [LiteratureReference:936759] Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4 [LiteratureReference:936882] Characterization of two genes for the human Na,K-ATPase beta subunit [LiteratureReference:936879] Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium [LiteratureReference:936846] Identification of the mammalian Na,K-ATPase 3 subunit [LiteratureReference:936902] Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit [LiteratureReference:936833] Alternating hemiplegia of childhood or familial hemiplegic migraine? A novel ATP1A2 mutation [LiteratureReference:936849] Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions [LiteratureReference:936798] Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism [LiteratureReference:2752101] A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ The Na+/K+-transporting ATPase trimer exchanges sodium for potassium
orthologousEvent	[Reaction:R-GGA-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Gallus gallus [Reaction:R-XTR-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Xenopus tropicalis [Reaction:R-DRE-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Danio rerio [Reaction:R-SSC-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Sus scrofa [Reaction:R-BTA-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Bos taurus [Reaction:R-CFA-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Canis familiaris [Reaction:R-RNO-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Rattus norvegicus [Reaction:R-MMU-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [SimpleEntity:R-ALL-29804] K+ [cytosol] 3 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[NegativeRegulation:9690307] Negative regulation by 'ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1014332] He, Lei, 2010-11-15
revised	[InstanceEdit:2752085] Jassal, Bijay, 2012-12-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-936897
summation	[Summation:936822] The sodium/potassium-transporting ATPase (ATP1A:ATP1B:FXYD) ...
updateTrackers	[UpdateTracker:9787754] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v44:[add_removeLiteratureReference, modifyText] [UpdateTracker:9776735] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v74:[addRegulator] [UpdateTracker:9783841] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v55:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787754] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v44:[add_removeLiteratureReference, modifyText] [UpdateTracker:9776735] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v74:[addRegulator] [UpdateTracker:9783841] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v55:[modifyText]
(hasEvent)	[Pathway:R-HSA-5578775] Ion homeostasis [Pathway:R-HSA-936837] Ion transport by P-type ATPases

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