Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Ion homeostasis
Stable Identifier
R-HSA-5578775
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
Ion channels and ion homeostasis in relation to cardiac conduction is described in this section (Couette et al. 2006, Bartos et al. 2015).
Literature References
PubMed ID
Title
Journal
Year
17017901
Physiological and pharmacological insights into the role of ionic channels in cardiac pacemaker activity
Marger, L
,
Couette, B
,
Mangoni, ME
,
Nargeot, J
Cardiovasc Hematol Disord Drug Targets
2006
26140724
Ion Channels in the Heart
Grandi, E
,
Ripplinger, CM
,
Bartos, DC
Compr Physiol
2015
Participants
Events
SLC8A1,2,3 exchange 3Na+ for Ca2+
(Homo sapiens)
DMPK phosphorylates PLN
(Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen
(Homo sapiens)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
(Homo sapiens)
ATP1A:ATP1B:FXYD binds cardiac glycosides
(Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol
(Homo sapiens)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol
(Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol
(Homo sapiens)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it
(Homo sapiens)
TRPC1 translocates calcium from the extracellular region to the cytosol
(Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol
(Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region
(Homo sapiens)
ATP2B4 binds to NOS1, inhibiting it
(Homo sapiens)
PRKACA phosphorylates PLN
(Homo sapiens)
PRKACA phosphorylates TNNI3
(Homo sapiens)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol
(Homo sapiens)
KCNJ11:ABCC9 binds nicorandil
(Homo sapiens)
Participates
as an event of
Cardiac conduction (Homo sapiens)
Event Information
Go Biological Process
regulation of cardiac conduction (1903779)
Orthologous Events
Ion homeostasis (Bos taurus)
Ion homeostasis (Caenorhabditis elegans)
Ion homeostasis (Canis familiaris)
Ion homeostasis (Danio rerio)
Ion homeostasis (Dictyostelium discoideum)
Ion homeostasis (Drosophila melanogaster)
Ion homeostasis (Gallus gallus)
Ion homeostasis (Mus musculus)
Ion homeostasis (Plasmodium falciparum)
Ion homeostasis (Rattus norvegicus)
Ion homeostasis (Saccharomyces cerevisiae)
Ion homeostasis (Schizosaccharomyces pombe)
Ion homeostasis (Sus scrofa)
Ion homeostasis (Xenopus tropicalis)
Authored
Jassal, B (2014-06-02)
Reviewed
Colotti, G (2015-11-09)
Created
Jassal, B (2014-06-02)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text